Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp4a3provided by RGD
Official Full Name: cytochrome P450, family 4, subfamily a, polypeptide 3provided by RGD
Primary source: RGD:631356
See related: EnsemblRapid:ENSRNOG00000066878 AllianceGenome:RGD:631356
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CYPIVA3; Cyp4a14
Summary: Enables alkane 1-monooxygenase activity and arachidonate monooxygenase activity. Involved in several processes, including fatty acid metabolic process; icosanoid biosynthetic process; and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 7330.7) and Liver (RPKM 3198.1) See more
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Genomic context

Location:: 5q35

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134334396..134352268, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129097571..129115488, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (134468666..134484851, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study provides a link between CYP4A14 and NAFLD. Overexpression of CYP4A14 promotes, whereas gene disruption of CYP4A14 attenuates, HFD- and MCD-induced liver lipid accumulation. Ablation of CYP4A14 gene markedly attenuates liver damage, inflammation, and fibrosis in MCD-induced NASH.
Title: Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.
NO differentially regulates the function of CYP4A1, -4A2, and -4A3 isoforms in the renal vasculature and the nephron.
Title: Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat.
identification of the specific pattern of cytochrome P450-4A isoform expression in arterioles and parenchymal cells of the skeletal muscle microcirculation reveals that CYP450-4A3 mRNA was expressed in isolated muscle fibers and in cremasteric arterioles
Title: Expression of cytochrome P450-4A isoforms in the rat cremaster muscle microcirculation.
that NO interacts with CYP4A proteins in a distinct manner and it interferes with renal microvessel 20-HETE synthesis, which may play an important role in the regulation of blood pressure and renal function during pregnancy.
Title: Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131600 (e-PCR)
- UniSTS:214883

D5Wox12 (e-PCR)
- UniSTS:118123

Cyp4a14 (e-PCR), detects polymorphism
- UniSTS:463007

D5Mcw1 (e-PCR)
- UniSTS:240078

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alkane 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkane 1-monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables arachidonate monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in icosanoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in icosanoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lauric acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in linoleic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to 3-methylcholanthrene	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4A14

Names: CYPIVA14; P450-LA-omega 3; cytochrome P450 4A3; cytochrome P450, family 4, subfamily a, polypeptide 14; cytochrome P450-LA-omega 3; long-chain fatty acid omega-monooxygenase

NP_786936.1

EC 1.14.14.80

XP_038965516.1

EC 1.14.14.80

XP_038965517.1

EC 1.14.14.80

XP_038965518.1

EC 1.14.14.80

XP_063143470.1

EC 1.14.14.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175760.2 → NP_786936.1 cytochrome P450 4A14

See identical proteins and their annotated locations for NP_786936.1

Status: PROVISIONAL

Source sequence(s)

M33936

UniProtKB/Swiss-Prot

P20817

UniProtKB/TrEMBL

F1M7X1

Related

ENSRNOP00000041025.6, ENSRNOT00000051385.8

Conserved Domains (1) summary

pfam00067
Location:52 → 502

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

134334396..134352268 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287400.1 → XP_063143470.1 cytochrome P450 4A14 isoform X2

UniProtKB/TrEMBL

A6JZ41, D3ZHZ6, F1M7X1
XM_039109590.2 → XP_038965518.1 cytochrome P450 4A14 isoform X1

UniProtKB/TrEMBL

F1M7X1

Conserved Domains (1) summary

cd20678
Location:69 → 506

CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z
XM_039109589.2 → XP_038965517.1 cytochrome P450 4A14 isoform X1

UniProtKB/TrEMBL

F1M7X1

Conserved Domains (1) summary

cd20678
Location:69 → 506

CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z
XM_039109588.2 → XP_038965516.1 cytochrome P450 4A14 isoform X1

UniProtKB/TrEMBL

F1M7X1

Conserved Domains (1) summary

cd20678
Location:69 → 506

CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z