Sec15 Secretory 15 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sec15provided by FlyBase
Official Full Name: Secretory 15provided by FlyBase
Primary source: FLYBASE:FBgn0266674
Locus tag: Dmel_CG7034
See related: AllianceGenome:FB:FBgn0266674
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3R41; CG7034; Dmel\CG7034; dsec15; sec15; Sec15p
Summary: Enables small GTPase binding activity. Involved in several processes, including border follicle cell migration; endocytic recycling; and phototaxis. Located in axon terminus and recycling endosome. Part of exocyst. Is expressed in adult head; lamina; and ommatidial precursor cluster. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to several human genes including EXOC6B (exocyst complex component 6B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93B12-93B12; 3-70 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21105046..21107972, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16930768..16933694, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ.
Title: The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ.
dynamic expression patterns of DSec15mRNA and Sec15 protein during wild type embryonic as well as larval development of Drosophila
Title: Developmental expression, co-localization and genetic interaction of exocyst component Sec15 with Rab11 during Drosophila development.
The Sec15 protein, a known Rab11 effector and a component of the exocyst, is necessary for Notch activation and the resolution of distinct sibling cell fates in the sensory organ precursors lineage.
Title: Recycling polarity.
The Sec15 protein, a known Rab11 effector and a component of the exocyst, is necessary for Notch activation and the resolution of distinct sibling cell fates in the sensory organ precursors lineage.
Title: Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.
The Sec15 protein, a known Rab11 effector and a component of the exocyst, is necessary for Notch activation and the resolution of distinct sibling cell fates in the sensory organ precursors lineage.
Title: Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.
In fly photoreceptors Sec15 colocalizes with Rab11 and that loss of Sec15 affects rhabdomere morphology.
Title: Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle tethering involved in exocytosis	IC Inferred by Curator more info	PubMed
involved_in vesicle tethering involved in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed