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    CdGAPr Cd GTPase activating protein-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CdGAPrprovided by FlyBase
    Official Full Name
    Cd GTPase activating protein-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032821
    Locus tag
    Dmel_CG10538
    See related
    AllianceGenome:FB:FBgn0032821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10538; cdGAPr; CG10538; d-CdGAPr; Dmel\CG10538; FBgn 32821; GAP
    Summary
    Predicted to enable GTPase activator activity. Involved in retinal ganglion cell axon guidance. Is expressed in several structures, including embryonic segment posterior compartment; epithelium; organism subdivision; and peripheral sensory precursor cell. Orthologous to several human genes including ARHGAP32 (Rho GTPase activating protein 32). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CdGAPr in Genome Data Viewer
    Location:
    38A3-38A3; 2-54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19774874..19791882, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19774874..19791882, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene fructose-1,6-bisphosphatase Neighboring gene brain-specific homeobox Neighboring gene female sterile (2) ltoPP43 Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U4 at 38AB Neighboring gene sickie

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic expression of d-CdGAPr, a novel Drosophila melanogaster gene encoding a GTPase activating protein. Sagnier T, et al. Mech Dev, 2000 Jun. PMID 10842085
    2. Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk. Murakami S, et al. Development, 2007 Apr. PMID 17360775
    3. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
    4. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Hu H, et al. Proc Natl Acad Sci U S A, 2005 Mar 22. PMID 15755809, Free PMC Article
    5. RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion. Fic W, et al. J Cell Biol, 2021 Apr 5. PMID 33646271, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Cd GTPase activating protein-related
    Names
    CG10538-PA
    CG10538-PB
    CG10538-PC
    CG10538-PD
    CdGAPr-PA
    CdGAPr-PB
    CdGAPr-PC
    CdGAPr-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19774874..19791882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273671.2 → NP_001260600.1  Cd GTPase activating protein-related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260600.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6AWI4, Q8MSV9, Q9NCL1, Q9VIS1
      UniProtKB/TrEMBL
      M9PDR8
      Conserved Domains (4) summary
      cd11835
      Location:299 → 358
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:420 → 613
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:168 → 274
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl23733
      Location:1322 → 1457
      FliJ; Flagellar FliJ protein

    2. NM_136158.5 → NP_610002.1  Cd GTPase activating protein-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6AWI4, Q8MSV9, Q9NCL1, Q9VIS1
      UniProtKB/TrEMBL
      M9PDR8
      Related
      FBpp0080851
      Conserved Domains (4) summary
      cd11835
      Location:299 → 358
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:420 → 613
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:168 → 274
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl23733
      Location:1322 → 1457
      FliJ; Flagellar FliJ protein

    3. NM_001169547.2 → NP_001163018.1  Cd GTPase activating protein-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHM0
      Conserved Domains (4) summary
      cd11835
      Location:299 → 358
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:420 → 613
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:168 → 274
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl23733
      Location:1321 → 1456
      FliJ; Flagellar FliJ protein

    4. NM_001169546.2 → NP_001163017.1  Cd GTPase activating protein-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHM1
      Conserved Domains (4) summary
      cd11835
      Location:299 → 358
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:420 → 613
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:168 → 274
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl23733
      Location:1321 → 1456
      FliJ; Flagellar FliJ protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHM0 E1JHM0
    E1JHM1 E1JHM1
    M9PDR8 M9PDR8
    Q9VIS1.2 Q9VIS1

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