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    Rgk1 Rad, Gem/Kir family member 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 14462605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rgk1provided by FlyBase
    Official Full Name
    Rad, Gem/Kir family member 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0264753
    Locus tag
    Dmel_CG44011
    See related
    AllianceGenome:FB:FBgn0264753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30127; CG44011; CG9811; CT27512; Dmel\CG44011; rgk1; RGK1
    Old locus tag
    Dmel_CG30127; Dmel_CG9811
    Summary
    Enables calcium channel regulator activity. Involved in anesthesia-resistant memory and medium-term memory. Located in presynapse. Is expressed in several structures, including Kenyon cell; dorsal pharyngeal muscle cell; embryonic hindgut; embryonic/larval garland cell; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rgk1 in Genome Data Viewer
    Location:
    56C10-56D1; 2-89 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19311148..19356525, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15198653..15244030, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Acyl-CoA dehydrogenase very long chain Neighboring gene Endophilin B Neighboring gene uncharacterized protein Neighboring gene wurstfest Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two Components of Aversive Memory in Drosophila, Anesthesia-Sensitive and Anesthesia-Resistant Memory, Require Distinct Domains Within the Rgk1 Small GTPase. Murakami S, et al. J Neurosci, 2017 May 31. PMID 28416593, Free PMC Article
    2. The Hox transcription factor Ultrabithorax binds RNA and regulates co-transcriptional splicing through an interplay with RNA polymerase II. Carnesecchi J, et al. Nucleic Acids Res, 2022 Jan 25. PMID 34931250, Free PMC Article
    3. Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split. Puhl HL 3rd, et al. PLoS One, 2014. PMID 24992013, Free PMC Article
    4. A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Geuking P, et al. Genetics, 2005 Dec. PMID 16079232, Free PMC Article
    5. Effectors of alcohol-induced cell killing in Drosophila. Chen P, et al. Cell Death Differ, 2012 Oct. PMID 22539005, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anesthesia-resistant memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in medium-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rad, Gem/Kir family member 1
    Names
    CG44011-PA
    CG44011-PB
    CG44011-PC
    Rgk1-PA
    Rgk1-PB
    Rgk1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19311148..19356525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274158.1 → NP_001261087.1  Rad, Gem/Kir family member 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A076N653, A0A0B4KFV9
      Conserved Domains (2) summary
      smart00010
      Location:240 → 421
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cl21455
      Location:240 → 514
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_166341.3 → NP_725875.3  Rad, Gem/Kir family member 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725875.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBJ6
      Conserved Domains (3) summary
      smart00010
      Location:1121 → 1286
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      pfam11179
      Location:459 → 715
      DUF2967; Protein of unknown function (DUF2967)
      cl21455
      Location:1121 → 1379
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_137567.3 → NP_611411.2  Rad, Gem/Kir family member 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611411.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A076N653, A1ZBJ5, Q6NR39
      Conserved Domains (2) summary
      smart00010
      Location:240 → 405
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cl21455
      Location:240 → 498
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFV9 A0A0B4KFV9
    A1ZBJ6 A1ZBJ6
    Q6NR39 Q6NR39

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials