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    Vps15 Vacuolar protein sorting 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41096, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vps15provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0260935
    Locus tag
    Dmel_CG9746
    See related
    AllianceGenome:FB:FBgn0260935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9746; Dmel\CG9746; dVps15; FBgn0260935; ird; ird1; Ird1; p150; vps15; VPS15
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; larval midgut cell programmed cell death; and neuron remodeling. Part of phosphatidylinositol 3-kinase complex, class III, type I. Is expressed in adult head. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Vps15 in Genome Data Viewer
    Location:
    85D1-85D2; 3-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9240757..9245869, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5066479..5071591, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pumilio Neighboring gene long non-coding RNA:CR45196 Neighboring gene uncharacterized protein Neighboring gene D1 chromosomal protein Neighboring gene Sulfotransferase 2

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation PubMed 
    involved_in epithelial structure maintenance PubMed 
    involved_in establishment or maintenance of cell polarity PubMed 
    involved_in larval midgut cell programmed cell death PubMed 
    involved_in late endosome to vacuole transport  
    involved_in late endosome to vacuole transport  
    involved_in macroautophagy  
    involved_in macroautophagy PubMed 
    involved_in macroautophagy PubMed 
    involved_in neuron remodeling PubMed 
    involved_in pexophagy  
    involved_in protein phosphorylation  
    involved_in protein targeting to vacuole  
    involved_in regulation of antimicrobial peptide production PubMed 
    Component Evidence Code Pubs
    is_active_in late endosome  
    is_active_in nucleus-vacuole junction  
    part_of phosphatidylinositol 3-kinase complex, class III, type I  
    part_of phosphatidylinositol 3-kinase complex, class III, type I PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II  

    General protein information

    Preferred Names
    vacuolar protein sorting 15
    Names
    CG9746-PA
    CG9746-PB
    CG9746-PC
    Vps15-PA
    Vps15-PB
    Vps15-PC
    immune response deficient 1
    immune response-deficient 1
    NP_001163565.1
    NP_001262405.1
    NP_649868.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9240757..9245869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141611.2 → NP_649868.1  vacuolar protein sorting 15, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHH2
      Related
      FBpp0081466
      Conserved Domains (6) summary
      smart00220
      Location:41 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG2319
      Location:958 → 1342
      WD40; WD40 repeat [General function prediction only]
      cd13980
      Location:27 → 325
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:483 → 508
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:1020 → 1063
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:953 → 1240
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001275476.1 → NP_001262405.1  vacuolar protein sorting 15, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262405.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGX5
      Conserved Domains (3) summary
      smart00220
      Location:41 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13980
      Location:27 → 325
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:483 → 508
      HEAT; HEAT repeat [structural motif]
    3. NM_001170094.2 → NP_001163565.1  vacuolar protein sorting 15, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIG3
      Conserved Domains (3) summary
      smart00220
      Location:41 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13980
      Location:27 → 325
      STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
      sd00044
      Location:483 → 508
      HEAT; HEAT repeat [structural motif]
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