NFAT NFAT nuclear factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: NFATprovided by FlyBase
Official Full Name: NFAT nuclear factorprovided by FlyBase
Primary source: FLYBASE:FBgn0030505
Locus tag: Dmel_CG11172
See related: AllianceGenome:FB:FBgn0030505
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11172; Dmel\CG11172; dNFAT; EP1335; MESR1; NF-AT5; Nfat; NFAT5
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of synaptic vesicle exocytosis and response to salt stress. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including adult mushroom body dorsal accessory calyx; anal pad primordium; calyx of adult mushroom body; embryonic anal pad; and embryonic hindgut. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1); NFATC3 (nuclear factor of activated T cells 3); and NFAT5 (nuclear factor of activated T cells 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12A9-12B2; 1-44 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13624745..13664568)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13518778..13558601)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nur77 is a novel negative-feedback regulator of pulmonary artery smooth muscle cell proliferation through inhibition of the signal transducer and activator of transcription 3/Pim-1/nuclear factor of activated T cells axis
Title: Nur77 suppresses pulmonary artery smooth muscle cell proliferation through inhibition of the STAT3/Pim-1/NFAT pathway.
We propose that NFAT regulates pre-synaptic development and constrains long-term plasticity by dampening neuronal excitability
Title: NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2166 (e-PCR)
- UniSTS:80244

fb33b12.x1 (e-PCR)
- UniSTS:190403

Dm0470 (e-PCR)
- UniSTS:67531

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NFAT nuclear factor

Names: CG11172-PA; CG11172-PB; CG11172-PC; CG11172-PD; CG11172-PE; CG11172-PG; CG11172-PH; NFAT homolog; NFAT-PA; NFAT-PB; NFAT-PC; NFAT-PD; NFAT-PE; NFAT-PG; NFAT-PH; Rel domain protein; drosophila TonEBP; misexpression suppressor of Ras 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13624745..13664568

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078592.3 → NP_511147.2 NFAT nuclear factor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511147.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYA6

Related

FBpp0073639

Conserved Domains (2) summary

cd07882
Location:464 → 627

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cl15674
Location:631 → 749

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001272597.2 → NP_001259526.2 NFAT nuclear factor, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259526.2

Status: REVIEWED

UniProtKB/TrEMBL

A2VEY8, M9PH25

Conserved Domains (2) summary

cd07882
Location:255 → 418

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cl15674
Location:422 → 540

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001169275.2 → NP_001162746.1 NFAT nuclear factor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162746.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GU53

Conserved Domains (2) summary

cd07882
Location:255 → 418

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cl15674
Location:422 → 540

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001298290.1 → NP_001285219.1 NFAT nuclear factor, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285219.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJP5

Conserved Domains (2) summary

cd07882
Location:293 → 456

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cl15674
Location:460 → 578

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001169274.2 → NP_001162745.1 NFAT nuclear factor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162745.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJP5

Conserved Domains (2) summary

cd07882
Location:293 → 456

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cl15674
Location:460 → 578

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001103504.2 → NP_001096974.1 NFAT nuclear factor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096974.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JUV3

Conserved Domains (2) summary

cd07882
Location:502 → 665

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cl15674
Location:669 → 787

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001169276.3 → NP_001162747.1 NFAT nuclear factor, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162747.1

Status: REVIEWED

UniProtKB/TrEMBL

A2VEY8, E1JJP6

Conserved Domains (2) summary

cd07882
Location:293 → 456

RHD-n_TonEBP; N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP)

cl15674
Location:460 → 578

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...