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    lrrfip1a leucine rich repeat (in FLII) interacting protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 407677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lrrfip1aprovided by ZNC
    Official Full Name
    leucine rich repeat (in FLII) interacting protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-99
    See related
    Ensembl:ENSDARG00000030012 AllianceGenome:ZFIN:ZDB-GENE-030131-99
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lrrfip1; zeh1367; hm:zeh1367; wu:fc06b04; wu:fi15c07
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Is expressed in adaxial cell; cardiovascular system; musculature system; retina; and somite. Orthologous to human LRRFIP1 (LRR binding FLII interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lrrfip1a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (24065983..24115035)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (24255068..24304795)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene atypical chemokine receptor 3a Neighboring gene tRNA-yW synthesizing protein 5 Neighboring gene matrix AAA peptidase interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome. Rodríguez-Ruiz L, et al. EMBO Mol Med, 2023 Oct 11. PMID 37675820, Free PMC Article
    2. Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration. Tobia C, et al. Front Immunol, 2019. PMID 31156639, Free PMC Article
    3. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Le X, et al. Development, 2013 Jun. PMID 23615277, Free PMC Article
    4. Transcription factors underlying photoreceptor diversity. Angueyra JM, et al. Elife, 2023 Feb 6. PMID 36745553, Free PMC Article
    5. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat flightless-interacting protein 1; dentin sialophosphoprotein; enolase-phosphatase E1; leucine-rich repeat flightless-interacting protein 2; uncharacterized protein lrrfip1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      24065983..24115035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478924.2 → XP_021334599.1  uncharacterized protein lrrfip1a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9QBC1
      Conserved Domains (1) summary
      pfam09738
      Location:315 → 662
      LRRFIP; LRRFIP family

    2. XM_021478939.2 → XP_021334614.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QBD2, A0A8M9QK65
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 474
      LRRFIP; LRRFIP family

    3. XM_021478932.2 → XP_021334607.1  uncharacterized protein lrrfip1a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9Q321
      Conserved Domains (1) summary
      pfam09738
      Location:275 → 622
      LRRFIP; LRRFIP family

    4. XM_021478941.2 → XP_021334616.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QG03, A0A8M9QK65
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 434
      LRRFIP; LRRFIP family

    5. XM_021478942.2 → XP_021334617.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PSV0, A0A8M9QK65, H1A5Y8
      Related
      ENSDARP00000092350.6, ENSDART00000101577.7
      Conserved Domains (2) summary
      pfam09738
      Location:50 → 410
      LRRFIP; LRRFIP family
      cl25732
      Location:160 → 281
      SMC_N; RecF/RecN/SMC N terminal domain

    6. XM_021478944.2 → XP_021334619.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8M9QBD6, A0A8M9QK65
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 348
      LRRFIP; LRRFIP family

    7. XM_068223616.1 → XP_068079717.1  uncharacterized protein lrrfip1a isoform X21

      UniProtKB/TrEMBL
      A0A8M9PA40

    8. XM_068223617.1 → XP_068079718.1  dentin sialophosphoprotein isoform X22

      UniProtKB/TrEMBL
      A0A8M9PA40

    9. XM_068223614.1 → XP_068079715.1  uncharacterized protein lrrfip1a isoform X19

      UniProtKB/TrEMBL
      A0A8M9PA40

    10. XM_068223608.1 → XP_068079709.1  uncharacterized protein lrrfip1a isoform X13

      UniProtKB/TrEMBL
      A0A8M9PA40

    11. XM_068223615.1 → XP_068079716.1  uncharacterized protein lrrfip1a isoform X20

      UniProtKB/TrEMBL
      A0A8M9PA40

    12. XM_068223605.1 → XP_068079706.1  uncharacterized protein lrrfip1a isoform X10

      UniProtKB/TrEMBL
      A0A8M9PA40

    13. XM_068223612.1 → XP_068079713.1  enolase-phosphatase E1 isoform X17

      UniProtKB/TrEMBL
      A0A8M9PA40

    14. XM_068223606.1 → XP_068079707.1  uncharacterized protein lrrfip1a isoform X11

      UniProtKB/TrEMBL
      A0A8M9PA40

    15. XM_068223610.1 → XP_068079711.1  enolase-phosphatase E1 isoform X15

      UniProtKB/TrEMBL
      A0A8M9PA40

    16. XM_068223607.1 → XP_068079708.1  uncharacterized protein lrrfip1a isoform X12

      UniProtKB/TrEMBL
      A0A8M9PA40

    17. XM_068223609.1 → XP_068079710.1  uncharacterized protein lrrfip1a isoform X14

      UniProtKB/TrEMBL
      A0A8M9PA40

    18. XM_068223613.1 → XP_068079714.1  enolase-phosphatase E1 isoform X18

      UniProtKB/TrEMBL
      A0A8M9PA40

    19. XM_068223611.1 → XP_068079712.1  uncharacterized protein lrrfip1a isoform X16

      UniProtKB/TrEMBL
      A0A8M9PA40

    20. XM_068223619.1 → XP_068079720.1  leucine-rich repeat flightless-interacting protein 1 isoform X24

      UniProtKB/TrEMBL
      A0A8M9QK65

    21. XM_068223621.1 → XP_068079722.1  leucine-rich repeat flightless-interacting protein 2 isoform X26

    22. XM_068223622.1 → XP_068079723.1  leucine-rich repeat flightless-interacting protein 2 isoform X27

    23. XM_068223618.1 → XP_068079719.1  leucine-rich repeat flightless-interacting protein 1 isoform X23

      UniProtKB/TrEMBL
      A0A8M9QK65

    24. XM_068223620.1 → XP_068079721.1  leucine-rich repeat flightless-interacting protein 1 isoform X25

      UniProtKB/TrEMBL
      A0A8M9QK65
      Related
      ENSDARP00000111467.2, ENSDART00000126198.3

    25. XM_021478943.2 → XP_021334618.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8M2BF13, A0A8M9QK65
      Conserved Domains (1) summary
      pfam09738
      Location:25 → 401
      LRRFIP; LRRFIP family

    26. XM_021478930.2 → XP_021334605.1  uncharacterized protein lrrfip1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9PSJ5
      Conserved Domains (1) summary
      pfam09738
      Location:282 → 629
      LRRFIP; LRRFIP family

    27. XM_021478937.2 → XP_021334612.1  uncharacterized protein lrrfip1a isoform X4

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9PSU5
      Conserved Domains (1) summary
      pfam09738
      Location:242 → 589
      LRRFIP; LRRFIP family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394753.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      181272..228393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009304700.4 → XP_009302975.1  leucine-rich repeat flightless-interacting protein 2 isoform X42

      UniProtKB/TrEMBL
      A0A8M3BCG7
      Conserved Domains (2) summary
      TIGR04211
      Location:630 → 716
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:315 → 653
      LRRFIP; LRRFIP family

    2. XM_021472187.2 → XP_021327862.1  leucine-rich repeat flightless-interacting protein 2 isoform X43

      UniProtKB/TrEMBL
      A0A8M9PA47
      Conserved Domains (2) summary
      TIGR04211
      Location:568 → 654
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:315 → 591
      LRRFIP; LRRFIP family

    3. XM_021472174.2 → XP_021327849.1  uncharacterized protein lrrfip1a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9QBC1
      Conserved Domains (1) summary
      pfam09738
      Location:315 → 662
      LRRFIP; LRRFIP family

    4. XM_021472184.2 → XP_021327859.1  uncharacterized protein lrrfip1a isoform X35

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9PSK0
      Conserved Domains (1) summary
      pfam09738
      Location:315 → 600
      LRRFIP; LRRFIP family

    5. XM_021472176.2 → XP_021327851.1  uncharacterized protein lrrfip1a isoform X30

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9PZR4
      Conserved Domains (2) summary
      pfam09738
      Location:315 → 638
      LRRFIP; LRRFIP family
      pfam15619
      Location:388 → 509
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

    6. XM_021472186.2 → XP_021327861.1  uncharacterized protein lrrfip1a isoform X38

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9Q531
      Conserved Domains (1) summary
      pfam09738
      Location:315 → 576
      LRRFIP; LRRFIP family

    7. XM_021472181.2 → XP_021327856.1  enolase-phosphatase E1 isoform X33

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9PZR9
      Conserved Domains (1) summary
      pfam09738
      Location:274 → 621
      LRRFIP; LRRFIP family

    8. XM_068218540.1 → XP_068074641.1  uncharacterized protein lrrfip1a isoform X36

      UniProtKB/TrEMBL
      A0A8M9PA40

    9. XM_068218542.1 → XP_068074643.1  dentin sialophosphoprotein isoform X39

      UniProtKB/TrEMBL
      A0A8M9PA40

    10. XM_009304693.4 → XP_009302968.1  uncharacterized protein lrrfip1a isoform X28

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9QK54
      Conserved Domains (1) summary
      pfam09738
      Location:305 → 652
      LRRFIP; LRRFIP family

    11. XM_068218541.1 → XP_068074642.1  uncharacterized protein lrrfip1a isoform X37

      UniProtKB/TrEMBL
      A0A8M9PA40

    12. XM_009304695.4 → XP_009302970.1  enolase-phosphatase E1 isoform X32

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9QFZ6
      Conserved Domains (1) summary
      pfam09738
      Location:278 → 625
      LRRFIP; LRRFIP family

    13. XM_021472175.2 → XP_021327850.1  uncharacterized protein lrrfip1a isoform X29

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9QFZ3
      Conserved Domains (1) summary
      pfam09738
      Location:295 → 642
      LRRFIP; LRRFIP family

    14. XM_021472178.2 → XP_021327853.1  uncharacterized protein lrrfip1a isoform X31

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9PLF4
      Conserved Domains (1) summary
      pfam09738
      Location:285 → 632
      LRRFIP; LRRFIP family

    15. XM_021472183.2 → XP_021327858.1  enolase-phosphatase E1 isoform X34

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9QK63
      Conserved Domains (1) summary
      pfam09738
      Location:258 → 605
      LRRFIP; LRRFIP family

    16. XM_009304699.4 → XP_009302974.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QBD2, A0A8M9QK65
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 474
      LRRFIP; LRRFIP family

    17. XM_068218544.1 → XP_068074645.1  leucine-rich repeat flightless-interacting protein 1 isoform X41

      UniProtKB/TrEMBL
      A0A8M9QK65

    18. XM_068218543.1 → XP_068074644.1  leucine-rich repeat flightless-interacting protein 1 isoform X40

      UniProtKB/TrEMBL
      A0A8M9QK65

    19. XM_021472180.2 → XP_021327855.1  uncharacterized protein lrrfip1a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9Q321
      Conserved Domains (1) summary
      pfam09738
      Location:275 → 622
      LRRFIP; LRRFIP family

    20. XM_005167635.4 → XP_005167692.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QG03, A0A8M9QK65
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 434
      LRRFIP; LRRFIP family

    21. XM_005167636.4 → XP_005167693.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PSV0, A0A8M9QK65, H1A5Y8
      Conserved Domains (2) summary
      pfam09738
      Location:50 → 410
      LRRFIP; LRRFIP family
      cl25732
      Location:160 → 281
      SMC_N; RecF/RecN/SMC N terminal domain

    22. XM_005167639.4 → XP_005167696.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8M9QBD6, A0A8M9QK65
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 348
      LRRFIP; LRRFIP family

    23. XM_005167637.5 → XP_005167694.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8M2BF13, A0A8M9QK65
      Conserved Domains (1) summary
      pfam09738
      Location:25 → 401
      LRRFIP; LRRFIP family

    24. XM_021472179.2 → XP_021327854.1  uncharacterized protein lrrfip1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9PSJ5
      Conserved Domains (1) summary
      pfam09738
      Location:282 → 629
      LRRFIP; LRRFIP family

    25. XM_021472185.2 → XP_021327860.1  uncharacterized protein lrrfip1a isoform X4

      UniProtKB/TrEMBL
      A0A8M9PA40, A0A8M9PSU5
      Conserved Domains (1) summary
      pfam09738
      Location:242 → 589
      LRRFIP; LRRFIP family
    Nucleotide Protein Strain
    Heading Accession and Version

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