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    pld2 phospholipase D2 [ Danio rerio (zebrafish) ]

    Gene ID: 565743, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pld2provided by ZNC
    Official Full Name
    phospholipase D2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060216-4
    See related
    Ensembl:ENSDARG00000034262 AllianceGenome:ZFIN:ZDB-GENE-060216-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable N-acylphosphatidylethanolamine-specific phospholipase D activity; phosphatidylinositol binding activity; and phospholipase D activity. Predicted to act upstream of or within intracellular signal transduction; lipid catabolic process; and phosphatidic acid biosynthetic process. Is expressed in yolk syncytial layer. Orthologous to human PLD2 (phospholipase D2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See pld2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (38387285..38438944, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37790106..37838803, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 2 Neighboring gene misshapen-like kinase 1 Neighboring gene uncharacterized LOC137490148 Neighboring gene cholinergic receptor, nicotinic, epsilon Neighboring gene glycolipid transfer protein domain containing 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to mediate lipid and glucose metabolism. Liu HY, et al. Biochim Biophys Acta, 2010 Dec. PMID 20816853
    2. C9orf72 is essential for neurodevelopment and motility mediated by Cyclin G1. Yeh TH, et al. Exp Neurol, 2018 Jun. PMID 29522758
    3. n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish. Zhao Y, et al. Appl Microbiol Biotechnol, 2020 Mar. PMID 31950220
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase D2
    XP_005165435.1
    XP_009299966.1
    XP_021327317.1
    XP_021327319.1
    XP_068077564.1
    XP_694649.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      38387285..38438944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689557.9 → XP_694649.4  phospholipase D2 isoform X1

      See identical proteins and their annotated locations for XP_694649.4

      UniProtKB/TrEMBL
      A0A8M2BCW6
      Related
      ENSDARP00000039697.7, ENSDART00000039698.7
      Conserved Domains (5) summary
      cd07297
      Location:56 → 182
      PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
      cd09843
      Location:323 → 467
      PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
      cd09845
      Location:628 → 809
      PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
      PLN02866
      Location:81 → 939
      PLN02866; phospholipase D
      cd01254
      Location:171 → 297
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    2. XM_009301691.4 → XP_009299966.1  phospholipase D2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ASP7
      Conserved Domains (5) summary
      cd07297
      Location:56 → 182
      PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
      cd09845
      Location:616 → 797
      PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
      PLN02866
      Location:81 → 927
      PLN02866; phospholipase D
      cd01254
      Location:171 → 297
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      cl15239
      Location:323 → 455
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    3. XM_005165378.5 → XP_005165435.1  phospholipase D2 isoform X1

      See identical proteins and their annotated locations for XP_005165435.1

      UniProtKB/TrEMBL
      A0A8M2BCW6
      Related
      ENSDARP00000122561.1, ENSDART00000131912.3
      Conserved Domains (5) summary
      cd07297
      Location:56 → 182
      PX_PLD2; The phosphoinositide binding Phox Homology domain of Phospholipase D2
      cd09843
      Location:323 → 467
      PLDc_vPLD2_1; Catalytic domain, repeat 1, of vertebrate phospholipase D2
      cd09845
      Location:628 → 809
      PLDc_vPLD2_2; Catalytic domain, repeat 2, of vertebrate phospholipase D2
      PLN02866
      Location:81 → 939
      PLN02866; phospholipase D
      cd01254
      Location:171 → 297
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    4. XM_068221463.1 → XP_068077564.1  phospholipase D2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCW6

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394597.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      122428..171085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471644.2 → XP_021327319.1  phospholipase D2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PR22
      Conserved Domains (1) summary
      cl26365
      Location:81 → 927
      PLN03008; Phospholipase D delta

    2. XM_021471642.2 → XP_021327317.1  phospholipase D2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P8Y7
      Conserved Domains (1) summary
      cl26365
      Location:81 → 939
      PLN03008; Phospholipase D delta
    Nucleotide Protein Strain
    Heading Accession and Version

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