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    bco2l beta-carotene 15, 15-dioxygenase 2, like [ Danio rerio (zebrafish) ]

    Gene ID: 84041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bco2lprovided by ZNC
    Official Full Name
    beta-carotene 15, 15-dioxygenase 2, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010509-1
    See related
    Ensembl:ENSDARG00000027620 AllianceGenome:ZFIN:ZDB-GENE-010509-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bcdo2; bcdo2l; fk59e08; b-diox-II; wu:fk59e08
    Summary
    Enables 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity. Acts upstream of or within negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Located in mitochondrion. Is expressed in blood cell; digestive system; head; pericardial region; and trunk. Orthologous to human BCO2 (beta-carotene oxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bco2l in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26121352..26130610)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25521255..25530371)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-214j8.15 Neighboring gene elastase 3 like Neighboring gene si:ch211-214j8.12 Neighboring gene dihydrofolate reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon. Helgeland H, et al. Gene, 2014 Jun 15. PMID 24583166
    2. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. Kiefer C, et al. J Biol Chem, 2001 Apr 27. PMID 11278918
    3. BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway. Lobo GP, et al. Development, 2012 Aug. PMID 22764054, Free PMC Article
    4. Hepatic gene expression profiling using Genechips in zebrafish exposed to 17alpha-ethynylestradiol. Hoffmann JL, et al. Aquat Toxicol, 2006 Sep 12. PMID 16872691
    5. Insight into molecular pathways of retinal metabolism, associated with vitellogenesis in zebrafish. Levi L, et al. Am J Physiol Endocrinol Metab, 2012 Mar 15. PMID 22205629

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-carotene 15,15'-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carotenoid dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carotene catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-carotene 15, 15-dioxygenase 2, like
    Names
    etID19516.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131799.1 → NP_571874.1  beta-carotene 15, 15-dioxygenase 2, like

      See identical proteins and their annotated locations for NP_571874.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ290391
      UniProtKB/TrEMBL
      Q90WH3
      Related
      ENSDARP00000013052.7, ENSDART00000002221.8
      Conserved Domains (1) summary
      pfam03055
      Location:35 → 545
      RPE65; Retinal pigment epithelial membrane protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      26121352..26130610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476337.2 → XP_021332012.1  beta-carotene 15, 15-dioxygenase 2, like isoform X1

      UniProtKB/TrEMBL
      A0A8M9PKL8
      Conserved Domains (1) summary
      pfam03055
      Location:36 → 537
      RPE65; Retinal pigment epithelial membrane protein

    2. XM_068221328.1 → XP_068077429.1  beta-carotene 15, 15-dioxygenase 2, like isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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