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    magi2a membrane associated guanylate kinase, WW and PDZ domain containing 2a [ Danio rerio (zebrafish) ]

    Gene ID: 564112, updated on 4-Jan-2025

    Summary

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    Official Symbol
    magi2aprovided by ZNC
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050810-4
    See related
    Ensembl:ENSDARG00000021590 AllianceGenome:ZFIN:ZDB-GENE-050810-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    magi2; fb82g11; wu:fb82g11; si:dkey-97c7.1; si:dkeyp-86a5.1
    Summary
    Predicted to enable SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within pronephric glomerulus development. Predicted to be located in membrane. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Is expressed in pronephric glomerulus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See magi2a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22755465..23083187, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (23034490..23362212, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 Neighboring gene nucleoporin 107 Neighboring gene uncharacterized LOC137491549 Neighboring gene solute carrier family 35 member E3 Neighboring gene MDM2 proto-oncogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Corticosteroid treatment exacerbates nephrotic syndrome in a zebrafish model of magi2a knockout. Jobst-Schwan T, et al. Kidney Int, 2019 May. PMID 31010479, Free PMC Article
    2. Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance. Dong L, et al. J Am Soc Nephrol, 2015 Sep. PMID 25556170, Free PMC Article
    3. Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp. Fink IR, et al. Mol Immunol, 2015 Feb. PMID 25306962
    4. Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. He Z, et al. Biochem Biophys Res Commun, 2019 Sep 10. PMID 31349972, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-1 adrenergic receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables type II activin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pronephric glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a
    Names
    membrane associated guanylate kinase, WW and PDZ domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327853.1 → NP_001314782.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a

      Status: PROVISIONAL

      Source sequence(s)
      AL935183, AL935187, BX897665, CR392369
      UniProtKB/TrEMBL
      A0A8M1P8D6, A0A8M6Z5C9, F1Q897
      Related
      ENSDARP00000019515.9, ENSDART00000009768.9
      Conserved Domains (5) summary
      smart00228
      Location:431 → 511
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:307 → 337
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:1182 → 1262
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:352 → 381
      WW; WW domain
      cl17190
      Location:122 → 286
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      22755465..23083187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017355040.3 → XP_017210529.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X19

      UniProtKB/TrEMBL
      A0A8M6YX18, A0A8M6Z5C9

    2. XM_017355042.3 → XP_017210531.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X18

      UniProtKB/TrEMBL
      A0A8M6YY10, A0A8M6Z5C9

    3. XM_068219691.1 → XP_068075792.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X16

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    4. XM_068219683.1 → XP_068075784.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X9

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    5. XM_068219685.1 → XP_068075786.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X11

      UniProtKB/TrEMBL
      A0A8M6Z5Z3

    6. XM_068219684.1 → XP_068075785.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X10

      UniProtKB/TrEMBL
      A0A8M6YZJ4

    7. XM_068219680.1 → XP_068075781.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X6

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    8. XM_068219677.1 → XP_068075778.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    9. XM_068219679.1 → XP_068075780.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    10. XM_068219678.1 → XP_068075779.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X4

      UniProtKB/TrEMBL
      A0A8M9PHB4

    11. XM_068219682.1 → XP_068075783.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X8

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    12. XM_068219681.1 → XP_068075782.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X7

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    13. XM_068219676.1 → XP_068075777.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    14. XM_068219675.1 → XP_068075776.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z5C9

    15. XM_017355045.3 → XP_017210534.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X17

      UniProtKB/TrEMBL
      A0A8M6YX22, A0A8M6Z5D1
      Related
      ENSDARP00000118891.1, ENSDART00000133644.3

    16. XM_068219690.1 → XP_068075791.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X15

      UniProtKB/TrEMBL
      A0A8M6Z5D1

    17. XM_068219687.1 → XP_068075788.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X13

      UniProtKB/TrEMBL
      A0A8M6Z5D1

    18. XM_068219686.1 → XP_068075787.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X12

      UniProtKB/TrEMBL
      A0A8M6Z5D1

    19. XM_068219688.1 → XP_068075789.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X14

      UniProtKB/TrEMBL
      A0A8M6YY15

    20. XM_068219689.1 → XP_068075790.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2a isoform X14

      UniProtKB/TrEMBL
      A0A8M6YY15

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394554.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      5075..229652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395231.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      2859..258335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001122611.1: Suppressed sequence

      Description
      NM_001122611.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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