U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    gtf2f1 general transcription factor IIF, polypeptide 1 [ Danio rerio (zebrafish) ]

    Gene ID: 325832, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    gtf2f1provided by ZNC
    Official Full Name
    general transcription factor IIF, polypeptide 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4557
    See related
    Ensembl:ENSDARG00000032129 AllianceGenome:ZFIN:ZDB-GENE-030131-4557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rap74; C76800; fd13c08; zgc:56155; wu:fd13c08
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity and TFIIF-class transcription factor complex binding activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to act upstream of or within positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIF complex. Is expressed in telencephalon. Orthologous to human GTF2F1 (general transcription factor IIF subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gtf2f1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (33921971..33945791, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (33792553..33811811, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a Neighboring gene immediate early response 2a Neighboring gene alkB homolog 7 Neighboring gene immunoglobulin heavy constant delta Neighboring gene immunoglobulin heavy constant mu-like Neighboring gene immunoglobulin heavy variable 3-74-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Embryonic exposure to 10 μg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain. Lee J, et al. Metallomics, 2016 Jun 1. PMID 26776728
    2. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Jiang L, et al. Cell, 2013 May 9. PMID 23663777, Free PMC Article
    3. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
    4. BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Shi W, et al. J Immunol, 2019 Nov 1. PMID 31562209
    5. Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Boswell M, et al. Sci Rep, 2020 Feb 24. PMID 32094353, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TFIIF-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    general transcription factor IIF subunit 1
    Names
    general transcription factor IIF, polypeptide 1, 74kDa

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423629.1 → NP_001410558.1  general transcription factor IIF subunit 1

      Status: VALIDATED

      Source sequence(s)
      BX510335
      UniProtKB/TrEMBL
      Q7ZV95
      Related
      ENSDARP00000009277.7, ENSDART00000026090.9

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      33921971..33945791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215897.1 → XP_068071998.1  general transcription factor IIF subunit 1 isoform X1

    2. XM_068215900.1 → XP_068072001.1  general transcription factor IIF subunit 1 isoform X3

    3. XM_068215899.1 → XP_068072000.1  general transcription factor IIF subunit 1 isoform X2

    4. XM_068215901.1 → XP_068072002.1  general transcription factor IIF subunit 1 isoform X4

    5. XM_068215908.1 → XP_068072009.1  general transcription factor IIF subunit 1 isoform X6

      UniProtKB/TrEMBL
      Q7ZV95

    6. XM_068215906.1 → XP_068072007.1  general transcription factor IIF subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q7ZV95

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199729.1: Suppressed sequence

      Description
      NM_199729.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.