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    sass6 SAS-6 centriolar assembly protein [ Danio rerio (zebrafish) ]

    Gene ID: 406747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sass6provided by ZNC
    Official Full Name
    SAS-6 centriolar assembly proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2784
    See related
    Ensembl:ENSDARG00000058346 AllianceGenome:ZFIN:ZDB-GENE-040426-2784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55668; wu:fb98c12
    Summary
    Acts upstream of or within several processes, including embryonic cleavage; microtubule cytoskeleton organization; and spermatogenesis. Located in centrosome. Is expressed in blastomere and unfertilized egg. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 14. Orthologous to human SASS6 (SAS-6 centriolar assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sass6 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10735909..10752315, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10706227..10722597, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 14A Neighboring gene major facilitator superfamily domain containing 14A 1 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene transmembrane serine protease 9 Neighboring gene translocase of inner mitochondrial membrane 13 homolog (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structures of SAS-6 suggest its organization in centrioles. van Breugel M, et al. Science, 2011 Mar 4. PMID 21273447
    2. The zebrafish maternal-effect gene cellular atoll encodes the centriolar component sas-6 and defects in its paternal function promote whole genome duplication. Yabe T, et al. Dev Biol, 2007 Dec 1. PMID 17950723, Free PMC Article
    3. In vitro oocyte culture-based manipulation of zebrafish maternal genes. Nair S, et al. Dev Dyn, 2013 Jan. PMID 23074011, Free PMC Article
    4. Maternal control of vertebrate development before the midblastula transition: mutants from the zebrafish I. Dosch R, et al. Dev Cell, 2004 Jun. PMID 15177026
    5. The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization. Pfaff KL, et al. Mol Cell Biol, 2007 Aug. PMID 17576815, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes.[Cea]
      Title: The zebrafish maternal-effect gene cellular atoll encodes the centriolar component sas-6 and defects in its paternal function promote whole genome duplication.
    2. study determined the x-ray structure of the amino-terminal domain of SAS-6 and showed that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers
      Title: Structures of SAS-6 suggest its organization in centrioles.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in deuterosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    spindle assembly abnormal protein 6 homolog
    Names
    cea
    cellular atoll
    spindle assembly 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213438.1 → NP_998603.1  spindle assembly abnormal protein 6 homolog

      See identical proteins and their annotated locations for NP_998603.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045420
      UniProtKB/Swiss-Prot
      Q7ZVT3
      UniProtKB/TrEMBL
      B2GRL0
      Related
      ENSDARP00000075634.5, ENSDART00000081191.6
      Conserved Domains (2) summary
      COG1340
      Location:215 → 472
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam16531
      Location:46 → 140
      SAS-6_N; Centriolar protein SAS N-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      10735909..10752315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216275.1 → XP_068072376.1  spindle assembly abnormal protein 6 homolog isoform X5

    2. XM_009296095.4 → XP_009294370.1  spindle assembly abnormal protein 6 homolog isoform X4

      UniProtKB/TrEMBL
      A0A8M3AM46
      Conserved Domains (1) summary
      pfam16531
      Location:46 → 140
      SAS-6_N; Centriolar protein SAS N-terminal

    3. XM_068216274.1 → XP_068072375.1  spindle assembly abnormal protein 6 homolog isoform X3

    4. XM_068216273.1 → XP_068072374.1  spindle assembly abnormal protein 6 homolog isoform X2

    5. XM_005173944.5 → XP_005174001.1  spindle assembly abnormal protein 6 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M2BL83
      Conserved Domains (2) summary
      COG1340
      Location:215 → 472
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam16531
      Location:46 → 140
      SAS-6_N; Centriolar protein SAS N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZVT3.1 GenPept UniProtKB/Swiss-Prot:Q7ZVT3

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