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    rapgef1b Rap guanine nucleotide exchange factor (GEF) 1b [ Danio rerio (zebrafish) ]

    Gene ID: 394101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rapgef1bprovided by ZNC
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1001
    See related
    Ensembl:ENSDARG00000015971 AllianceGenome:ZFIN:ZDB-GENE-040426-1001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    GRF2; rapgef1; zgc:56372
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rapgef1b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (4116444..4223569)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (3951813..4055371)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene senataxin Neighboring gene netrin g2b Neighboring gene uridine-cytidine kinase 1 Neighboring gene DNL-type zinc finger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation. Li N, et al. Clin Genet, 2021 Aug. PMID 33834495
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation.
      Title: Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56372

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 1b
    Names
    Rap guanine nucleotide exchange factor (GEF) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328346.1 → NP_001315275.1  rap guanine nucleotide exchange factor 1b

      Status: VALIDATED

      Source sequence(s)
      CU570789, CU571253, FP085431
      UniProtKB/TrEMBL
      A0A8M1PA59, E7F4B2
      Related
      ENSDARP00000111128.2, ENSDART00000123759.3
      Conserved Domains (2) summary
      smart00147
      Location:947 → 1176
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:799 → 937
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      4116444..4223569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215815.1 → XP_068071916.1  rap guanine nucleotide exchange factor 1b isoform X5

    2. XM_068215819.1 → XP_068071920.1  rap guanine nucleotide exchange factor 1b isoform X11

    3. XM_068215816.1 → XP_068071917.1  rap guanine nucleotide exchange factor 1b isoform X6

    4. XM_068215820.1 → XP_068071921.1  rap guanine nucleotide exchange factor 1b isoform X12

    5. XM_021468780.2 → XP_021324455.1  rap guanine nucleotide exchange factor 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PTQ9
      Conserved Domains (3) summary
      smart00147
      Location:963 → 1192
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:815 → 953
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl26464
      Location:287 → 538
      Atrophin-1; Atrophin-1 family

    6. XM_021468781.2 → XP_021324456.1  rap guanine nucleotide exchange factor 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PQB1
      Conserved Domains (3) summary
      smart00147
      Location:962 → 1191
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:814 → 952
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl26464
      Location:287 → 537
      Atrophin-1; Atrophin-1 family

    7. XM_021468783.2 → XP_021324458.1  rap guanine nucleotide exchange factor 1b isoform X7

      UniProtKB/TrEMBL
      A0A8M9PCJ2
      Conserved Domains (3) summary
      smart00147
      Location:914 → 1143
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:766 → 904
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl26464
      Location:287 → 538
      Atrophin-1; Atrophin-1 family

    8. XM_021468782.2 → XP_021324457.1  rap guanine nucleotide exchange factor 1b isoform X3

      UniProtKB/TrEMBL
      A0A8M9P382
      Conserved Domains (3) summary
      smart00147
      Location:942 → 1171
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:794 → 932
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl26464
      Location:196 → 517
      Atrophin-1; Atrophin-1 family

    9. XM_068215814.1 → XP_068071915.1  rap guanine nucleotide exchange factor 1b isoform X4

    10. XM_021468784.2 → XP_021324459.1  rap guanine nucleotide exchange factor 1b isoform X8

      UniProtKB/TrEMBL
      A0A8M9PI61
      Conserved Domains (3) summary
      smart00147
      Location:860 → 1089
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:712 → 850
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cl26464
      Location:272 → 538
      Atrophin-1; Atrophin-1 family

    11. XM_068215817.1 → XP_068071918.1  rap guanine nucleotide exchange factor 1b isoform X9

    12. XM_068215818.1 → XP_068071919.1  rap guanine nucleotide exchange factor 1b isoform X10

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201126.1: Suppressed sequence

      Description
      NM_201126.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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