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    Atp5mc3 ATP synthase membrane subunit c locus 3 [ Mus musculus (house mouse) ]

    Gene ID: 228033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp5mc3provided by MGI
    Official Full Name
    ATP synthase membrane subunit c locus 3provided by MGI
    Primary source
    MGI:MGI:2442035
    See related
    Ensembl:ENSMUSG00000018770 AllianceGenome:MGI:2442035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp5g3; 6030447M23
    Summary
    The protein encoded by this gene is a subunit of mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP synthesis during oxidative phosphorylation. This gene encodes subunit 9, which is present in multiple copies in the transmembrane part of the ATP synthase complex. Phenotype and gene expression profiles suggest correlations between this gene and alcoholism- and obesity-related phenotypes. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Sep 2014]
    Expression
    Ubiquitous expression in heart adult (RPKM 896.5), kidney adult (RPKM 502.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp5mc3 in Genome Data Viewer
    Location:
    2 C3; 2 43.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73738791..73742793, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73908447..73912464, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene chimerin 1, opposite strand 3 Neighboring gene chimerin 1 Neighboring gene STARR-seq mESC enhancer starr_04840 Neighboring gene STARR-seq mESC enhancer starr_04842 Neighboring gene activating transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_04843 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73705882-73706183 Neighboring gene STARR-positive B cell enhancer ABC_E809 Neighboring gene STARR-positive B cell enhancer ABC_E4468 Neighboring gene predicted gene 10822 Neighboring gene predicted gene, 39851 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective. Huang Y, et al. Genet Mol Res, 2013 Sep 18. PMID 24085430, Free PMC Article
    2. Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Vrbacký M, et al. Hum Mol Genet, 2016 Nov 1. PMID 28173120
    3. Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Yao Y, et al. Nat Commun, 2020 Jul 30. PMID 32732898, Free PMC Article
    4. Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Li C, et al. Adv Sci (Weinh), 2024 Mar. PMID 38196272, Free PMC Article
    5. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We obtained correlations between Atp5g3 and alcoholism- and obesity-relevant phenotypes.
      Title: Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124584

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ligand-gated channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cation channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase F(0) complex subunit C3, mitochondrial
    Names
    ATP synthase lipid-binding protein, mitochondrial
    ATP synthase proteolipid P3
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
    ATPase protein 9
    ATPase subunit c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301721.1 → NP_001288650.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_001288650.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AI851824, AL844581, CF104340, CX208968
      Consensus CDS
      CCDS16136.1
      UniProtKB/Swiss-Prot
      P56384
      UniProtKB/TrEMBL
      Q14BC2
      Related
      ENSMUSP00000107627.2, ENSMUST00000111996.8
      Conserved Domains (1) summary
      MTH00222
      Location:67 → 141
      ATP9; ATP synthase F0 subunit 9; Provisional

    2. NM_001301722.1 → NP_001288651.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform b precursor

      See identical proteins and their annotated locations for NP_001288651.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI851824, AL844581, AW554443, CF104340
      Conserved Domains (1) summary
      cl00466
      Location:67 → 89
      ATP-synt_C; ATP synthase subunit C

    3. NM_175015.3 → NP_778180.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_778180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AI851824, AL844581, CF104340
      Consensus CDS
      CCDS16136.1
      UniProtKB/Swiss-Prot
      P56384
      UniProtKB/TrEMBL
      Q14BC2
      Related
      ENSMUSP00000018914.3, ENSMUST00000018914.3
      Conserved Domains (1) summary
      MTH00222
      Location:67 → 141
      ATP9; ATP synthase F0 subunit 9; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      73738791..73742793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250178.2 → XP_030106038.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P56384
      UniProtKB/TrEMBL
      Q14BC2
      Conserved Domains (1) summary
      MTH00222
      Location:67 → 141
      ATP9; ATP synthase F0 subunit 9; Provisional

    2. XM_030250179.2 → XP_030106039.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00466
      Location:67 → 104
      ATP-synt_C; ATP synthase subunit C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56384.1 GenPept UniProtKB/Swiss-Prot:P56384

    Gene LinkOut

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