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    raf1a Raf-1 proto-oncogene, serine/threonine kinase a [ Danio rerio (zebrafish) ]

    Gene ID: 30716, updated on 4-Jan-2025

    Summary

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    Official Symbol
    raf1aprovided by ZNC
    Official Full Name
    Raf-1 proto-oncogene, serine/threonine kinase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-41
    See related
    Ensembl:ENSDARG00000096415 AllianceGenome:ZFIN:ZDB-GENE-990415-41
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    craf; raf1; c-raf
    Summary
    Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within heart development and regulation of MAPK cascade. Predicted to be located in plasma membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in blastoderm; blastomere; brain; and head. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    all
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    Genomic context

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    See raf1a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (4709802..4747278)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (4773877..4811692)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene glycoprotein IX platelet Neighboring gene CCHC-type zinc finger, nucleic acid binding protein a Neighboring gene synapsin IIa Neighboring gene vestigial-like family member 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor. Li D, et al. Nat Med, 2019 Jul. PMID 31263281
    2. Disrupting Rb-Raf-1 interaction inhibits hair cell regeneration in zebrafish lateral line neuromasts. Lin Q, et al. Neuroreport, 2013 Mar 6. PMID 23381351
    3. Functional analysis of a phosphatidic acid binding domain in human Raf-1 kinase: mutations in the phosphatidate binding domain lead to tail and trunk abnormalities in developing zebrafish embryos. Ghosh S, et al. J Biol Chem, 2003 Nov 14. PMID 12925535
    4. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Razzaque MA, et al. Nat Genet, 2007 Aug. PMID 17603482
    5. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. Bögershausen N, et al. J Clin Invest, 2015 Sep. PMID 26280580, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cdk10 has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
      Title: Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression.
    2. Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
      Title: Disrupting Rb-Raf-1 interaction inhibits hair cell regeneration in zebrafish lateral line neuromasts.
    3. analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
      Title: Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model.
    4. Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
      Title: Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Raf-1 proto-oncogene, serine/threonine kinase a; raf-1 proto-oncogene, serine/threonine kinase a
    Names
    murine leukemia viral oncogene homolog
    serine/threonine protein kinase RAF1
    v-raf-1 murine leukemia viral oncogene homolog 1
    v-raf-1 murine leukemia viral oncogene homolog 1a
    NP_571514.2
    XP_017208994.1
    XP_017208996.1
    XP_021325405.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131439.2 → NP_571514.2  Raf-1 proto-oncogene, serine/threonine kinase a

      Status: VALIDATED

      Source sequence(s)
      CABZ01046288, CABZ01066947, CU468010, CU571070, FO818741
      UniProtKB/TrEMBL
      A0A0R4IN14, A0A8M1P820
      Related
      ENSDARP00000137636.2, ENSDART00000163860.2
      Conserved Domains (4) summary
      cd01816
      Location:50 → 124
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14149
      Location:332 → 614
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00069
      Location:346 → 601
      Pkinase; Protein kinase domain
      pfam00130
      Location:132 → 180
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      4709802..4747278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353505.2 → XP_017208994.1  raf-1 proto-oncogene, serine/threonine kinase a isoform X2

      UniProtKB/TrEMBL
      D3KYU7
      Conserved Domains (4) summary
      cd01816
      Location:50 → 124
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14149
      Location:315 → 597
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00069
      Location:329 → 584
      Pkinase; Protein kinase domain
      pfam00130
      Location:132 → 180
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. XM_021469730.2 → XP_021325405.1  raf-1 proto-oncogene, serine/threonine kinase a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PWA5
      Conserved Domains (3) summary
      cd01816
      Location:50 → 124
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14149
      Location:317 → 599
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:132 → 180
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. XM_017353507.2 → XP_017208996.1  raf-1 proto-oncogene, serine/threonine kinase a isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z3N3
      Related
      ENSDARP00000130779.2, ENSDART00000166503.2
    Nucleotide Protein Strain
    Heading Accession and Version

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