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    Hspa2 heat shock protein family A (Hsp70) member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hspa2provided by RGD
    Official Full Name
    heat shock protein family A (Hsp70) member 2provided by RGD
    Primary source
    RGD:620664
    See related
    EnsemblRapid:ENSRNOG00000006472 AllianceGenome:RGD:620664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hst70; Hspt70
    Summary
    Enables protein-folding chaperone binding activity and tau protein binding activity. Predicted to be involved in several processes, including negative regulation of inclusion body assembly; positive regulation of ATPase-coupled calcium transmembrane transporter activity; and protein folding. Predicted to act upstream of or within several processes, including male meiosis I; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Predicted to be located in cell surface; meiotic spindle; and nucleus. Predicted to be part of CatSper complex. Predicted to be active in cytosol; nucleus; and plasma membrane. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 1456.3) and Kidney (RPKM 68.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hspa2 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (100864172..100866946)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95128504..95131281)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99433575..99436288)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene uncharacterized LOC120103556 Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene uncharacterized LOC102556012

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evaluation of heat-shock protein A2 (HSPA2) in male rats before and after varicocele induction. Afiyani AA, et al. Mol Reprod Dev, 2014 Aug. PMID 25043441
    2. Isolation and nucleotide sequence analysis of the rat testis-specific major heat-shock protein (HSP70)-related gene. Wiśniewski J, et al. Biochim Biophys Acta, 1990 Jan 30. PMID 1688714
    3. Expression and sulfogalactolipid binding specificity of the recombinant testis-specific cognate heat shock protein 70. Mamelak D, et al. Glycoconj J, 1997 Sep. PMID 9337084
    4. HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes. Dix DJ, et al. Development, 1997 Nov. PMID 9409676
    5. Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene. Scieglińska D, et al. Biochem J, 2004 May 1. PMID 14766014, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSPA2 abundance increased whereas ubiquitin expression reduced in the affected testis of a rat varicocele model.
      Title: Evaluation of heat-shock protein A2 (HSPA2) in male rats before and after varicocele induction.
    2. high-level testis-specific gene expression requires additional sequences localized upstream of the T2 transcription start site
      Title: Location of promoter elements necessary and sufficient to direct testis-specific expression of the Hst70/Hsp70.2 gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93458

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycolipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tau protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within synaptonemal complex disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CatSper complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heat shock-related 70 kDa protein 2
    Names
    HST
    heat shock 70kDa protein 2
    heat shock protein 2
    heat shock protein 70.2
    heat shock protein alpha 2
    heat shock protein family A member 2
    testis-specific heat shock protein-related gene hst70

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433314.1 → NP_001420243.1  heat shock-related 70 kDa protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P14659, Q66HL1
      UniProtKB/TrEMBL
      A6HCA7

    2. NM_021863.3 → NP_068635.1  heat shock-related 70 kDa protein 2

      See identical proteins and their annotated locations for NP_068635.1

      Status: VALIDATED

      Source sequence(s)
      X15705
      UniProtKB/Swiss-Prot
      P14659
      Related
      ENSRNOP00000008504.3, ENSRNOT00000008504.7
      Conserved Domains (2) summary
      cd10233
      Location:7 → 383
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:2 → 615
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      100864172..100866946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240247.5 → XP_006240309.1  heat shock-related 70 kDa protein 2 isoform X1

      Conserved Domains (1) summary
      PTZ00009
      Location:2 → 615
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14659.2 GenPept UniProtKB/Swiss-Prot:P14659

    Gene LinkOut

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