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    Miga1 mitoguardin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Miga1provided by RGD
    Official Full Name
    mitoguardin 1provided by RGD
    Primary source
    RGD:1559958
    See related
    EnsemblRapid:ENSRNOG00000056332 AllianceGenome:RGD:1559958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam73a; RGD1559958
    Summary
    Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in mitochondrial fusion. Predicted to be located in mitochondrion and plasma membrane. Orthologous to human MIGA1 (mitoguardin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 134.4), Kidney (RPKM 41.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Miga1 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243884071..243939059, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241224118..241279174, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257490729..257546846, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene far upstream element binding protein 1 Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene nexilin (F actin binding protein) Neighboring gene uncharacterized LOC120100974 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene zinc finger, ZZ-type containing 3 Neighboring gene uncharacterized LOC134485695 Neighboring gene adenylate kinase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. Zhang Y, et al. Mol Cell, 2016 Jan 7. PMID 26711011
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitoguardin 1
    Names
    family with sequence similarity 73, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433179.1 → NP_001420108.1  mitoguardin 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HWL1, D4A5P3

    2. NM_001433180.1 → NP_001420109.1  mitoguardin 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6ADJ1, A6HWL1, D4A5P3

    3. NM_001433181.1 → NP_001420110.1  mitoguardin 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6ADJ1, A6HWL1, D4A5P3

    4. NM_001433182.1 → NP_001420111.1  mitoguardin 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    5. NM_001433183.1 → NP_001420112.1  mitoguardin 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    6. NM_001433187.1 → NP_001420116.1  mitoguardin 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      243884071..243939059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103886.2 → XP_038959814.1  mitoguardin 1 isoform X4

      Related
      ENSRNOP00000090920.2, ENSRNOT00000095768.2
      Conserved Domains (1) summary
      pfam10265
      Location:27 → 571
      Miga; Mitoguardin

    2. XM_039103885.2 → XP_038959813.1  mitoguardin 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K2T2, A6HWL1, D4A5P3
      Related
      ENSRNOP00000072364.2, ENSRNOT00000089370.3
      Conserved Domains (1) summary
      pfam10265
      Location:27 → 572
      Miga; Mitoguardin

    3. XM_039103884.2 → XP_038959812.1  mitoguardin 1 isoform X2

      Conserved Domains (1) summary
      pfam10265
      Location:27 → 581
      Miga; Mitoguardin

    4. XM_039103882.2 → XP_038959810.1  mitoguardin 1 isoform X1

      UniProtKB/TrEMBL
      A6HWL1, D4A5P3
      Conserved Domains (1) summary
      pfam10265
      Location:27 → 582
      Miga; Mitoguardin

    5. XM_063282753.1 → XP_063138823.1  mitoguardin 1 isoform X4

    6. XM_063282752.1 → XP_063138822.1  mitoguardin 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K2T2, A6HWL1, D4A5P3

    7. XM_039103883.2 → XP_038959811.1  mitoguardin 1 isoform X1

      UniProtKB/TrEMBL
      A6HWL1, D4A5P3
      Conserved Domains (1) summary
      pfam10265
      Location:27 → 582
      Miga; Mitoguardin

    8. XM_039103889.2 → XP_038959817.1  mitoguardin 1 isoform X6

      Conserved Domains (1) summary
      pfam10265
      Location:27 → 265
      Miga; Mitoguardin

    9. XM_063282755.1 → XP_063138825.1  mitoguardin 1 isoform X6

    10. XM_063282754.1 → XP_063138824.1  mitoguardin 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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