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    PRKACA protein kinase cAMP-activated catalytic subunit alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 282322, updated on 1-Jan-2025

    Summary

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    Official Symbol
    PRKACAprovided by VGNC
    Official Full Name
    protein kinase cAMP-activated catalytic subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:50250
    See related
    BGD:BT12357; Ensembl:ENSBTAG00000006642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PRKACA in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (11592363..11610317)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100848715 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene small integral membrane protein 46 Neighboring gene sterile alpha motif domain containing 1 Neighboring gene chromosome 7 C19orf67 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate dependent protein kinase. Shoji S, et al. Biochemistry, 1983 Jul 19. PMID 6311252
    2. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Breitenlechner C, et al. Structure, 2003 Dec. PMID 14656443
    3. Signaling the signal, cyclic AMP-dependent protein kinase inhibition by insulin-formed H2O2 and reactivation by thioredoxin. de Piña MZ, et al. J Biol Chem, 2008 May 2. PMID 18326045
    4. Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential. Prade L, et al. Structure, 1997 Dec 15. PMID 9438863
    5. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. Engh RA, et al. J Biol Chem, 1996 Oct 18. PMID 8824261

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the response of the energy landscape upon cyclic AMP (cAMP) binding is domain specific of protein kinase A (PKA).
      Title: Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains.
    2. PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
      Title: Cytoplasmic kinases downstream of GPR30 suppress gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone secretion from bovine anterior pituitary cells.
    3. Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.
      Title: Probes of the mitochondrial cAMP-dependent protein kinase.
    4. These data strongly suggest that H(2)O(2) promotes the formation of an intersubunit disulfide bond, impairing cAMP-dependent PKA activation.
      Title: Signaling the signal, cyclic AMP-dependent protein kinase inhibition by insulin-formed H2O2 and reactivation by thioredoxin.
    5. structural basis of selectivity for protein kinase A in complex with Rho-kinase inhibitors by x-ray crystallography
      Title: Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase A regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase catalytic subunit alpha
    Names
    PKA C-alpha
    protein kinase, cAMP-dependent, catalytic, alpha
    NP_777009.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174584.3 → NP_777009.1  cAMP-dependent protein kinase catalytic subunit alpha

      See identical proteins and their annotated locations for NP_777009.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000007
      UniProtKB/Swiss-Prot
      P00517
      UniProtKB/TrEMBL
      A0A3Q1N5A9
      Related
      ENSBTAP00000008727.5, ENSBTAT00000008727.5
      Conserved Domains (1) summary
      cd14209
      Location:42 → 331
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      11592363..11610317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00517.3 GenPept UniProtKB/Swiss-Prot:P00517

    Gene LinkOut

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