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    Mettl15 methyltransferase 15, mitochondrial 12S rRNA N4-cytidine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295985, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mettl15provided by RGD
    Official Full Name
    methyltransferase 15, mitochondrial 12S rRNA N4-cytidineprovided by RGD
    Primary source
    RGD:1304978
    See related
    EnsemblRapid:ENSRNOG00000066683 AllianceGenome:RGD:1304978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304978
    Summary
    Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be active in mitochondrial matrix. Orthologous to several human genes including METTL15 (methyltransferase 15, mitochondrial 12S rRNA N4-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 25.1), Heart (RPKM 23.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl15 in Genome Data Viewer
    Location:
    3q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (116041480..116219011, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (95586855..95764392, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (100186106..100366148, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7, pseudogene 2 Neighboring gene ribosomal protein S6, pseudogene 12 Neighboring gene growth factor receptor bound protein 7, pseudogene 1 Neighboring gene kinesin family member 18A Neighboring gene transfer RNA alanine (anticodon GGC) 3 Neighboring gene adenosylhomocysteinase, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108934

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables rRNA (cytosine-N4-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (cytosine-N4-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA base methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    12S rRNA N4-methylcytidine (m4C) methyltransferase
    Names
    methyltransferase like 15
    probable methyltransferase-like protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024981.2 → NP_001020152.2  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001431510.1 → NP_001418439.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNZ7, F7F172

    3. NM_001431511.1 → NP_001418440.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNZ7, F7F172

    4. NM_001431512.1 → NP_001418441.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNZ7, F7F172

    5. NM_001431513.1 → NP_001418442.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNZ7, F7F172

    6. NM_001431514.1 → NP_001418443.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      116041480..116219011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234687.5 → XP_006234749.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    2. XM_008762086.3 → XP_008760308.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_008760308.1

      UniProtKB/TrEMBL
      A6HNZ7, F7F172
      Related
      ENSRNOP00000091130.1, ENSRNOT00000098239.2
      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    3. XM_017591566.3 → XP_017447055.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    4. XM_006234689.5 → XP_006234751.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006234751.1

      UniProtKB/TrEMBL
      A6HNZ7, F7F172
      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    5. XM_008762085.4 → XP_008760307.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_008760307.1

      UniProtKB/TrEMBL
      A6HNZ7, F7F172
      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    6. XM_008762084.4 → XP_008760306.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    7. XM_006234688.5 → XP_006234750.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006234750.1

      UniProtKB/TrEMBL
      A6HNZ7, F7F172
      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    8. XM_006234686.5 → XP_006234748.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    9. XM_017591567.3 → XP_017447056.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X1

      UniProtKB/TrEMBL
      A6HNZ7, F7F172
      Conserved Domains (1) summary
      PRK00050
      Location:72 → 406
      PRK00050; 16S rRNA m(4)C1402 methyltranserfase; Provisional

    10. XM_063283310.1 → XP_063139380.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X2

    11. XM_063283309.1 → XP_063139379.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X2

    12. XM_063283311.1 → XP_063139381.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X3

    13. XM_063283312.1 → XP_063139382.1  12S rRNA N4-methylcytidine (m4C) methyltransferase isoform X4

    RNA

    1. XR_010064579.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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