Trim2 tripartite motif-containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim2provided by RGD
Official Full Name: tripartite motif-containing 2provided by RGD
Primary source: RGD:1310981
See related: EnsemblRapid:ENSRNOG00000010124 AllianceGenome:RGD:1310981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable translation repressor activity and ubiquitin protein ligase activity. Involved in regulation of neuron apoptotic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 375.4), Kidney (RPKM 110.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (171798654..171950193, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (169500628..169652855, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (183145096..183223819, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma.
Title: MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma.
a role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance.
Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Rat285 (e-PCR), detects polymorphism
- UniSTS:227424

RH142568 (e-PCR)
- UniSTS:231815

AI103312 (e-PCR)
- UniSTS:250515

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing protein 2

Names: E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2; tripartite motif protein 2

NP_001102022.1

EC 2.3.2.27

XP_038958566.1

EC 2.3.2.27

XP_038958567.1

EC 2.3.2.27

XP_038958568.1

EC 2.3.2.27

XP_038958569.1

EC 2.3.2.27

XP_038958570.1

EC 2.3.2.27

XP_038958571.1

EC 2.3.2.27

XP_038958572.1

EC 2.3.2.27

XP_038958574.1

EC 2.3.2.27

XP_038958576.1

EC 2.3.2.27

XP_063138188.1

EC 2.3.2.27

XP_063138189.1

EC 2.3.2.27

XP_063138190.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108552.3 → NP_001102022.1 tripartite motif-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_001102022.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5ZV62, D3ZM62

Conserved Domains (6) summary

smart00502
Location:178 → 304

BBC; B-Box C-terminal domain

smart00557
Location:342 → 438

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:24 → 126

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:488 → 761

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:37 → 82

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:132 → 173

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
NM_001430453.1 → NP_001417382.1 tripartite motif-containing protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2K2M8, A0A8I5ZV62
NM_001430454.1 → NP_001417383.1 tripartite motif-containing protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5ZV62
NM_001430455.1 → NP_001417384.1 tripartite motif-containing protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5ZV62
NM_001430456.1 → NP_001417385.1 tripartite motif-containing protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5ZV62
NM_001430457.1 → NP_001417386.1 tripartite motif-containing protein 2 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

D3ZQG6

UniProtKB/TrEMBL

A0A8I5ZV62

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

171798654..171950193 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102646.2 → XP_038958574.1 tripartite motif-containing protein 2 isoform X8

Conserved Domains (6) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:7 → 109

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:471 → 748

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:20 → 65

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:115 → 156

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_063282118.1 → XP_063138188.1 tripartite motif-containing protein 2 isoform X6

Related

ENSRNOP00000072306.2, ENSRNOT00000085382.3
XM_039102642.2 → XP_038958570.1 tripartite motif-containing protein 2 isoform X5

UniProtKB/TrEMBL

A0A8I5ZV62

Conserved Domains (6) summary

smart00502
Location:187 → 313

BBC; B-Box C-terminal domain

smart00557
Location:351 → 447

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:33 → 135

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:497 → 774

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:46 → 91

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:141 → 182

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_039102644.2 → XP_038958572.1 tripartite motif-containing protein 2 isoform X8

Conserved Domains (6) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:7 → 109

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:471 → 748

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:20 → 65

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:115 → 156

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_039102639.2 → XP_038958567.1 tripartite motif-containing protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZV62, A0A8I5ZY23

Related

ENSRNOP00000082573.2, ENSRNOT00000107931.2

Conserved Domains (6) summary

smart00502
Location:222 → 348

BBC; B-Box C-terminal domain

smart00557
Location:386 → 482

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:68 → 170

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:532 → 805

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:81 → 126

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:176 → 217

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_039102638.2 → XP_038958566.1 tripartite motif-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZV62

Conserved Domains (6) summary

smart00502
Location:222 → 348

BBC; B-Box C-terminal domain

smart00557
Location:386 → 482

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:68 → 170

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:532 → 809

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:81 → 126

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:176 → 217

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_063282120.1 → XP_063138190.1 tripartite motif-containing protein 2 isoform X9
XM_039102643.2 → XP_038958571.1 tripartite motif-containing protein 2 isoform X7

Related

ENSRNOP00000060362.4, ENSRNOT00000067618.4

Conserved Domains (6) summary

smart00502
Location:178 → 304

BBC; B-Box C-terminal domain

smart00557
Location:342 → 438

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:24 → 126

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:488 → 765

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:37 → 82

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:132 → 173

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_039102648.2 → XP_038958576.1 tripartite motif-containing protein 2 isoform X8

UniProtKB/TrEMBL

A0A8I5ZV62

Conserved Domains (6) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:7 → 109

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:471 → 748

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:20 → 65

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:115 → 156

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_063282119.1 → XP_063138189.1 tripartite motif-containing protein 2 isoform X8

UniProtKB/TrEMBL

A0A8I5ZV62
XM_039102640.2 → XP_038958568.1 tripartite motif-containing protein 2 isoform X3

UniProtKB/TrEMBL

A0A8I5ZV62

Conserved Domains (6) summary

smart00502
Location:222 → 348

BBC; B-Box C-terminal domain

smart00557
Location:386 → 482

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:68 → 170

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:532 → 712

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:81 → 126

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:176 → 217

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_039102641.2 → XP_038958569.1 tripartite motif-containing protein 2 isoform X4

UniProtKB/TrEMBL

A0A8I5ZV62

Conserved Domains (7) summary

smart00502
Location:222 → 348

BBC; B-Box C-terminal domain

smart00557
Location:386 → 482

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:68 → 170

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:532 → 708

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd00162
Location:84 → 124

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19824
Location:176 → 217

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins

cl17238
Location:81 → 126

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain