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    Nap1l1 nucleosome assembly protein 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 53605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nap1l1provided by MGI
    Official Full Name
    nucleosome assembly protein 1-like 1provided by MGI
    Primary source
    MGI:MGI:1855693
    See related
    Ensembl:ENSMUSG00000058799 AllianceGenome:MGI:1855693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NAP-1; D10Ertd68e
    Summary
    Predicted to enable several functions, including chromatin binding activity; histone binding activity; and histone chaperone activity. Involved in positive regulation of neural precursor cell proliferation and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including blood; forebrain; genitourinary system; liver; and nucleus pulposus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human NAP1L1 (nucleosome assembly protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 94.0), CNS E14 (RPKM 38.5) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nap1l1 in Genome Data Viewer
    Location:
    10 D1; 10 58.67 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111308754..111334011)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111472882..111498150)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40761 Neighboring gene STARR-seq mESC enhancer starr_27865 Neighboring gene STARR-seq mESC enhancer starr_27868 Neighboring gene STARR-seq mESC enhancer starr_27869 Neighboring gene predicted gene, 30145 Neighboring gene STARR-seq mESC enhancer starr_27871 Neighboring gene STARR-seq mESC enhancer starr_27875 Neighboring gene STARR-positive B cell enhancer ABC_E5181 Neighboring gene STARR-positive B cell enhancer ABC_E6921 Neighboring gene STARR-positive B cell enhancer ABC_E10641 Neighboring gene predicted gene, 25117 Neighboring gene STARR-positive B cell enhancer ABC_E6922 Neighboring gene high mobility group box 2 pseudogene Neighboring gene pleckstrin homology like domain, family A, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5. Liang X, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Sep 25. PMID 36148951, Free PMC Article
    2. Knockdown of nucleosome assembly protein 1-like 1 promotes dimethyl sulfoxide-induced differentiation of P19CL6 cells into cardiomyocytes. Li L, et al. J Cell Biochem, 2012 Dec. PMID 22807403
    3. Nucleosome Assembly Protein 1-Like 1 (Nap1l1) Regulates the Proliferation of Murine Induced Pluripotent Stem Cells. Yan Y, et al. Cell Physiol Biochem, 2016. PMID 26824453
    4. Knockdown of nucleosome assembly protein 1-like 1 induces mesoderm formation and cardiomyogenesis via notch signaling in murine-induced pluripotent stem cells. Gong H, et al. Stem Cells, 2014 Jul. PMID 24648372
    5. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation. Dominguez F, et al. J Virol, 2021 Jul 26. PMID 34076483, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5.
      Title: NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5.
    2. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
      Title: NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
    3. These findings reveal an essential role for the Nap1l1 histone chaperone in cortical neurogenesis during early embryonic brain development.
      Title: Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain.
    4. Nap1l1 promotes the proliferation of iPSC attributable to G2/M transition caused by downregulation of p27 and p21, and upregulation of cyclin B1, the activation of AKT or ERK is involved in the process.
      Title: Nucleosome Assembly Protein 1-Like 1 (Nap1l1) Regulates the Proliferation of Murine Induced Pluripotent Stem Cells.
    5. The molecular interaction between DGKzeta and Nap1l1 was attenuated after hypoxic stress.
      Title: Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress.
    6. Downregulation of Nap1l1 significantly enhances mesodermal induction and subsequent cardiogenesis of murine induced pluripotent stem cells via inhibition of gamma-secretase-regulated Notch signaling.
      Title: Knockdown of nucleosome assembly protein 1-like 1 induces mesoderm formation and cardiomyogenesis via notch signaling in murine-induced pluripotent stem cells.
    7. Nap1l1 is a novel protein that regulates cardiomyocytes differentiation of P19CL6 cells induced by dimethyl sulfoxide.
      Title: Knockdown of nucleosome assembly protein 1-like 1 promotes dimethyl sulfoxide-induced differentiation of P19CL6 cells into cardiomyocytes.
    8. Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4.
      Title: Interaction between nucleosome assembly protein 1-like family members.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone chaperone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleosome assembly protein 1-like 1
    Names
    NAP-1-related protein
    brain protein DN38
    nucleosome assembly protein-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358932.1 → NP_001345861.1  nucleosome assembly protein 1-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK011301, AK012250, AW488539, BF458793, BM948894, BY253657
      UniProtKB/TrEMBL
      Q9CSP8
      Conserved Domains (1) summary
      pfam00956
      Location:15 → 280
      NAP; Nucleosome assembly protein (NAP)

    2. NM_001428957.1 → NP_001415886.1  nucleosome assembly protein 1-like 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166253
      UniProtKB/TrEMBL
      Q3TF41

    3. NM_001428958.1 → NP_001415887.1  nucleosome assembly protein 1-like 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166253
      UniProtKB/TrEMBL
      Q3TF41

    4. NM_001428959.1 → NP_001415888.1  nucleosome assembly protein 1-like 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC166253
      UniProtKB/TrEMBL
      Q3TF41

    5. NM_001428960.1 → NP_001415889.1  nucleosome assembly protein 1-like 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC166253
      UniProtKB/TrEMBL
      Q3TF41

    6. NM_001428961.1 → NP_001415890.1  nucleosome assembly protein 1-like 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC166253
      UniProtKB/TrEMBL
      Q9CSP8

    7. NM_015781.5 → NP_056596.1  nucleosome assembly protein 1-like 1 isoform 2

      See identical proteins and their annotated locations for NP_056596.1

      Status: VALIDATED

      Source sequence(s)
      AK011301, AK136161, BF458793
      Consensus CDS
      CCDS36058.1
      UniProtKB/Swiss-Prot
      P28656, Q3UL14
      UniProtKB/TrEMBL
      Q3TF41
      Related
      ENSMUSP00000070068.9, ENSMUST00000065917.16
      Conserved Domains (1) summary
      pfam00956
      Location:78 → 343
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      111308754..111334011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245178.2 → XP_030101038.1  nucleosome assembly protein 1-like 1 isoform X1

      UniProtKB/Swiss-Prot
      P28656, Q3UL14
      UniProtKB/TrEMBL
      Q3TF41
      Related
      ENSMUSP00000151750.2, ENSMUST00000217908.2
      Conserved Domains (1) summary
      pfam00956
      Location:78 → 343
      NAP; Nucleosome assembly protein (NAP)

    2. XM_030245179.1 → XP_030101039.1  nucleosome assembly protein 1-like 1 isoform X3

      UniProtKB/TrEMBL
      Q9CSP8
      Conserved Domains (1) summary
      pfam00956
      Location:15 → 280
      NAP; Nucleosome assembly protein (NAP)

    3. XM_036155892.1 → XP_036011785.1  nucleosome assembly protein 1-like 1 isoform X2

      UniProtKB/TrEMBL
      Q9CSP8
      Conserved Domains (1) summary
      pfam00956
      Location:35 → 302
      NAP; Nucleosome assembly protein (NAP)

    RNA

    1. XR_001779558.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001146707.1: Suppressed sequence

      Description
      NM_001146707.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NR_152558.1: Suppressed sequence

      Description
      NR_152558.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28656.2 GenPept UniProtKB/Swiss-Prot:P28656

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