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    CD40 CD40 molecule [ Pongo pygmaeus (Bornean orangutan) ]

    Gene ID: 129021946, updated on 26-Mar-2024

    Summary

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    Gene symbol
    CD40
    Gene description
    CD40 molecule
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pongo pygmaeus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    See CD40 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonPyg2-v2.0_pri (GCF_028885625.2) 21 NC_072394.2 (48675048..48686879)
    RS_2023_04 previous assembly NHGRI_mPonPyg2-v1.1-hic.freeze_pri (GCF_028885625.1) 20 NC_072393.1 (48668739..48680461)

    Chromosome 21 - NC_072394.2Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 5 Neighboring gene large ribosomal subunit protein eL13-like Neighboring gene cadherin 22 Neighboring gene solute carrier family 35 member C2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in CD40 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in TRIF-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to protozoan IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response-regulating cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of isotype switching to IgG isotypes IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CD40 receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028885625.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonPyg2-v2.0_pri Primary Assembly

    Genomic

    1. NC_072394.2 Reference NHGRI_mPonPyg2-v2.0_pri Primary Assembly

      Range
      48675048..48686879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054468014.2 → XP_054323989.1  tumor necrosis factor receptor superfamily member 5 isoform X3

    2. XM_063659600.1 → XP_063515670.1  tumor necrosis factor receptor superfamily member 5 isoform X4

    3. XM_054468011.2 → XP_054323986.1  tumor necrosis factor receptor superfamily member 5 isoform X1

    4. XM_054468012.2 → XP_054323987.1  tumor necrosis factor receptor superfamily member 5 isoform X2

    5. XM_054468015.2 → XP_054323990.1  tumor necrosis factor receptor superfamily member 5 isoform X4

    6. XM_054468017.2 → XP_054323992.1  tumor necrosis factor receptor superfamily member 5 isoform X6

    7. XM_054468016.2 → XP_054323991.1  tumor necrosis factor receptor superfamily member 5 isoform X5

    Nucleotide Protein
    Heading Accession and Version

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