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    JAK2 Janus kinase 2 [ Pan paniscus (pygmy chimpanzee) ]

    Gene ID: 100979742, updated on 3-Dec-2024

    Summary

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    Gene symbol
    JAK2
    Gene description
    Janus kinase 2
    See related
    Ensembl:ENSPPAG00000019000
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan paniscus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See JAK2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 11 NC_073260.2 (119420003..119589890, complement)
    RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 9 NC_073258.1 (119425950..119595837, complement)

    Chromosome 11 - NC_073260.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC117981626 Neighboring gene insulin like 4 Neighboring gene insulin like 6 Neighboring gene transcription factor E2-alpha-like Neighboring gene all trans-polyprenyl-diphosphate synthase PDSS1-like Neighboring gene casein kinase I-like Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene RNA terminal phosphate cyclase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase JAK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Genomic

    1. NC_073260.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

      Range
      119420003..119589890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_055092183.2 → XP_054948158.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8ZHT5, A0A2R8ZP32

    2. XM_003823367.5 → XP_003823415.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8ZHT5, A0A2R8ZP32
      Related
      ENSPPAP00000004545.1
      Conserved Domains (6) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:844 → 1127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143 → 261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39 → 134
      FERM_F1; FERM F1 ubiquitin-like domain

    3. XM_024930144.4 → XP_024785912.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8ZHT5, A0A2R8ZP32
      Related
      ENSPPAP00000004553.1
      Conserved Domains (6) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:844 → 1127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143 → 261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39 → 134
      FERM_F1; FERM F1 ubiquitin-like domain

    4. XM_063594498.1 → XP_063450568.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8ZHT5, A0A2R8ZP32

    5. XM_034967096.2 → XP_034822987.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8ZHT5, A0A2R8ZP32
      Conserved Domains (6) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:844 → 1127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143 → 261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39 → 134
      FERM_F1; FERM F1 ubiquitin-like domain

    6. XM_034967097.2 → XP_034822988.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8ZHT5, A0A2R8ZP32
      Conserved Domains (6) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:844 → 1127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143 → 261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39 → 134
      FERM_F1; FERM F1 ubiquitin-like domain

    7. XM_063594497.1 → XP_063450567.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8ZHT5, A0A2R8ZP32

    8. XM_034967098.3 → XP_034822989.1  tyrosine-protein kinase JAK2 isoform X2

      UniProtKB/TrEMBL
      A0A2R8ZP32
      Conserved Domains (6) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      pfam18377
      Location:143 → 261
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:39 → 134
      FERM_F1; FERM F1 ubiquitin-like domain
      cl21453
      Location:844 → 1020
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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