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    Abi2 abl-interactor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286928, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abi2provided by RGD
    Official Full Name
    abl-interactor 2provided by RGD
    Primary source
    RGD:628771
    See related
    EnsemblRapid:ENSRNOG00000017707 AllianceGenome:RGD:628771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; lens fiber cell morphogenesis; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within several processes, including generation of neurons; learning or memory; and peptidyl-tyrosine phosphorylation. Predicted to be located in several cellular components, including actin filament; filopodium tip; and lamellipodium. Predicted to be part of SCAR complex. Predicted to be active in several cellular components, including adherens junction; glutamatergic synapse; and postsynaptic actin cytoskeleton. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 483.5), Heart (RPKM 145.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Abi2 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69321072..69490630)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61827186..61905703)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67234612..67284504)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 2, pseudogene 1 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene uncharacterized LOC102547711 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding  
    enables identical protein binding  
    enables proline-rich region binding  
    enables signaling adaptor activity  
    enables signaling adaptor activity  
    contributes_to small GTPase binding  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction  
    acts_upstream_of_or_within camera-type eye development  
    acts_upstream_of_or_within cell migration  
    involved_in cell projection morphogenesis  
    acts_upstream_of_or_within dendrite development  
    acts_upstream_of_or_within learning or memory  
    involved_in lens fiber cell morphogenesis  
    involved_in mitophagy  
    involved_in neuron migration  
    acts_upstream_of_or_within neuron migration  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation  
    involved_in positive regulation of lamellipodium assembly  
    involved_in postsynapse organization  
    involved_in postsynaptic actin cytoskeleton organization  
    involved_in regulation of dendritic spine morphogenesis  
    involved_in zonula adherens assembly  
    Component Evidence Code Pubs
    part_of SCAR complex  
    part_of SCAR complex  
    located_in actin filament  
    is_active_in actin-based cell projection  
    is_active_in adherens junction  
    located_in adherens junction  
    located_in cytosol  
    located_in dendrite  
    is_active_in dendritic spine  
    located_in filopodium tip  
    is_active_in glutamatergic synapse  
    located_in intracellular membrane-bounded organelle  
    is_active_in lamellipodium  
    located_in lamellipodium  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in postsynaptic actin cytoskeleton  

    General protein information

    Preferred Names
    abl interactor 2
    Names
    rCG22366-like
    thyroid hormone responsive protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393698.1NP_001380627.1  abl interactor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6IPC7, F1LYA6
      Related
      ENSRNOP00000078426.2, ENSRNOT00000113763.2
      Conserved Domains (2) summary
      cd11972
      Location:413473
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93156
      Abi_HHR; Abl-interactor HHR
    2. NM_173143.2NP_775166.2  abl interactor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F1LYA6
      Conserved Domains (1) summary
      cd11972
      Location:384444
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      69321072..69490630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266759.1XP_063122829.1  abl interactor 2 isoform X11

      UniProtKB/TrEMBL
      A6IPC6, F1LYA6
    2. XM_063266783.1XP_063122853.1  abl interactor 2 isoform X33

      UniProtKB/TrEMBL
      A6IPC8, F1LYA6
    3. XM_063266777.1XP_063122847.1  abl interactor 2 isoform X27

      UniProtKB/TrEMBL
      F1LYA6
    4. XM_063266772.1XP_063122842.1  abl interactor 2 isoform X23

      UniProtKB/TrEMBL
      F1LYA6
    5. XM_063266748.1XP_063122818.1  abl interactor 2 isoform X1

      UniProtKB/TrEMBL
      F1LYA6
    6. XM_063266793.1XP_063122863.1  abl interactor 2 isoform X42

    7. XM_063266799.1XP_063122869.1  abl interactor 2 isoform X48

    8. XM_063266749.1XP_063122819.1  abl interactor 2 isoform X2

      UniProtKB/TrEMBL
      F1LYA6
    9. XM_063266795.1XP_063122865.1  abl interactor 2 isoform X44

      UniProtKB/TrEMBL
      A0A8I6AC48
    10. XM_063266755.1XP_063122825.1  abl interactor 2 isoform X7

      UniProtKB/TrEMBL
      F1LYA6
    11. XM_063266785.1XP_063122855.1  abl interactor 2 isoform X35

      UniProtKB/TrEMBL
      F1LYA6
      Related
      ENSRNOP00000050008.7, ENSRNOT00000050179.7
    12. XM_063266756.1XP_063122826.1  abl interactor 2 isoform X8

      UniProtKB/TrEMBL
      F1LYA6
    13. XM_063266768.1XP_063122838.1  abl interactor 2 isoform X19

      UniProtKB/TrEMBL
      A0A8I6AC48
      Related
      ENSRNOP00000099822.1, ENSRNOT00000162455.1
    14. XM_063266765.1XP_063122835.1  abl interactor 2 isoform X16

      UniProtKB/TrEMBL
      A0A8I6AC48
    15. XM_063266750.1XP_063122820.1  abl interactor 2 isoform X3

      UniProtKB/TrEMBL
      F1LYA6
    16. XM_063266763.1XP_063122833.1  abl interactor 2 isoform X15

      UniProtKB/TrEMBL
      A0A8I6AC48
      Related
      ENSRNOP00000080678.2, ENSRNOT00000117396.2
    17. XM_063266771.1XP_063122841.1  abl interactor 2 isoform X22

      UniProtKB/TrEMBL
      A0A8I6AC48
    18. XM_063266767.1XP_063122837.1  abl interactor 2 isoform X18

      UniProtKB/TrEMBL
      A0A8I6AC48
    19. XM_063266784.1XP_063122854.1  abl interactor 2 isoform X34

    20. XM_063266754.1XP_063122824.1  abl interactor 2 isoform X6

      UniProtKB/TrEMBL
      F1LYA6
    21. XM_063266762.1XP_063122832.1  abl interactor 2 isoform X14

      UniProtKB/TrEMBL
      F1LYA6
    22. XM_063266766.1XP_063122836.1  abl interactor 2 isoform X17

      UniProtKB/TrEMBL
      A0A8I6AC48
    23. XM_063266798.1XP_063122868.1  abl interactor 2 isoform X47

    24. XM_063266774.1XP_063122844.1  abl interactor 2 isoform X25

      UniProtKB/TrEMBL
      F1LYA6
      Related
      ENSRNOP00000112364.1, ENSRNOT00000149612.1
    25. XM_063266758.1XP_063122828.1  abl interactor 2 isoform X10

      UniProtKB/TrEMBL
      F1LYA6
    26. XM_063266770.1XP_063122840.1  abl interactor 2 isoform X21

      UniProtKB/TrEMBL
      F1LYA6
    27. XM_063266773.1XP_063122843.1  abl interactor 2 isoform X24

      UniProtKB/TrEMBL
      F1LYA6
    28. XM_063266787.1XP_063122857.1  abl interactor 2 isoform X36

      UniProtKB/TrEMBL
      A0A8I6AC48
    29. XM_063266778.1XP_063122848.1  abl interactor 2 isoform X28

      UniProtKB/TrEMBL
      A0A8I6AC48
    30. XM_063266751.1XP_063122821.1  abl interactor 2 isoform X4

      UniProtKB/TrEMBL
      F1LYA6
    31. XM_063266761.1XP_063122831.1  abl interactor 2 isoform X13

      UniProtKB/TrEMBL
      F1LYA6
    32. XM_063266752.1XP_063122822.1  abl interactor 2 isoform X5

      UniProtKB/TrEMBL
      F1LYA6
    33. XM_063266797.1XP_063122867.1  abl interactor 2 isoform X46

    34. XM_063266757.1XP_063122827.1  abl interactor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZLD3, F1LYA6
    35. XM_063266769.1XP_063122839.1  abl interactor 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZQU4, F1LYA6
    36. XM_063266776.1XP_063122846.1  abl interactor 2 isoform X26

      UniProtKB/TrEMBL
      F1LYA6
    37. XM_063266760.1XP_063122830.1  abl interactor 2 isoform X12

      UniProtKB/TrEMBL
      F1LYA6
      Related
      ENSRNOP00000078640.2, ENSRNOT00000096759.2
    38. XM_063266779.1XP_063122849.1  abl interactor 2 isoform X29

      UniProtKB/TrEMBL
      A0A8I5ZKW2, A0A8I6AC48
    39. XM_063266788.1XP_063122858.1  abl interactor 2 isoform X37

      UniProtKB/TrEMBL
      A0A8I6AC48
    40. XM_063266791.1XP_063122861.1  abl interactor 2 isoform X40

    41. XM_063266780.1XP_063122850.1  abl interactor 2 isoform X30

      UniProtKB/TrEMBL
      A0A8I6AC48
    42. XM_063266792.1XP_063122862.1  abl interactor 2 isoform X41

    43. XM_063266790.1XP_063122860.1  abl interactor 2 isoform X39

      UniProtKB/TrEMBL
      F1LYA6
    44. XM_063266782.1XP_063122852.1  abl interactor 2 isoform X32

      UniProtKB/TrEMBL
      F1LYA6
      Related
      ENSRNOP00000082875.2, ENSRNOT00000111854.2
    45. XM_063266794.1XP_063122864.1  abl interactor 2 isoform X43

      UniProtKB/TrEMBL
      A0A8I6AC48
    46. XM_063266789.1XP_063122859.1  abl interactor 2 isoform X38

      UniProtKB/TrEMBL
      F1LYA6
    47. XM_063266781.1XP_063122851.1  abl interactor 2 isoform X31

      UniProtKB/TrEMBL
      A0A8I5ZVR4, F1LYA6
    48. XM_063266796.1XP_063122866.1  abl interactor 2 isoform X45

      UniProtKB/TrEMBL
      A0A8I6AC48
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