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    Mrpl42 mitochondrial ribosomal protein L42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299743, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrpl42provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L42provided by RGD
    Primary source
    RGD:1304915
    See related
    EnsemblRapid:ENSRNOG00000042740 AllianceGenome:RGD:1304915
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrps32
    Summary
    Predicted to be located in mitochondrion and plasma membrane. Predicted to be part of mitochondrial large ribosomal subunit and mitochondrial small ribosomal subunit. Orthologous to human MRPL42 (mitochondrial ribosomal protein L42). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 471.4), Muscle (RPKM 419.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl42 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (32004863..32028640, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (30117977..30141757, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (36573654..36597497, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 2 Neighboring gene uncharacterized LOC134479868 Neighboring gene proteasome subunit alpha type-4-like Neighboring gene uncharacterized LOC102556774 Neighboring gene ubiquitin-conjugating enzyme E2N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
    2. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. Cavdar Koc E, et al. J Biol Chem, 2001 Jun 1. PMID 11279123
    3. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    4. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    28S ribosomal protein L42, mitochondrial; large ribosomal subunit protein mL42
    Names
    28S ribosomal protein S32, mitochondrial
    39S ribosomal protein L42, mitochondrial
    L42mt
    MRP-L42
    MRP-S32
    Mitochondrial 28S ribosomal protein S32, mitochondrial
    S32mt

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106782.1 → NP_001100252.1  28S ribosomal protein L42, mitochondrial

      See identical proteins and their annotated locations for NP_001100252.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      A0A8I5ZJH6, A6IG39, B5DEP4, F7FFN1
      Related
      ENSRNOP00000102311.1, ENSRNOT00000128223.1
      Conserved Domains (1) summary
      pfam10210
      Location:45 → 141
      MRP-S32; Mitochondrial 28S ribosomal protein S32

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      32004863..32028640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765315.4 → XP_008763537.1  large ribosomal subunit protein mL42 isoform X1

      See identical proteins and their annotated locations for XP_008763537.1

      UniProtKB/TrEMBL
      A0A8I5ZJH6, A6IG39, B5DEP4, F7FFN1
      Conserved Domains (1) summary
      pfam10210
      Location:45 → 141
      MRP-S32; Mitochondrial 28S ribosomal protein S32

    2. XM_063263205.1 → XP_063119275.1  large ribosomal subunit protein mL42 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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