Babam2 BRISC and BRCA1 A complex member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Babam2provided by RGD
Official Full Name: BRISC and BRCA1 A complex member 2provided by RGD
Primary source: RGD:735111
See related: EnsemblRapid:ENSRNOG00000004364 AllianceGenome:RGD:735111
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to be located in cytosol and nucleus. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 268.8), Heart (RPKM 137.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (30089065..30467508, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (24369021..24788416, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (25666654..26135888, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BE100943 (e-PCR)
- UniSTS:249875

RH130268 (e-PCR)
- UniSTS:213555

D6Rat157 (e-PCR), detects polymorphism
- UniSTS:228000

AU028729 (e-PCR)
- UniSTS:112044

D6Rat178 (e-PCR), detects polymorphism
- UniSTS:228016

BI302086 (e-PCR)
- UniSTS:247534

Kcmf1 (e-PCR), detects polymorphism
- UniSTS:531453

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA repair	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRCA1-A complex	IEA Inferred from Electronic Annotation more info
part_of BRCA1-A complex	ISO Inferred from Sequence Orthology more info
part_of BRCA1-A complex	ISS Inferred from Sequence or Structural Similarity more info
part_of BRISC complex	IEA Inferred from Electronic Annotation more info
part_of BRISC complex	ISO Inferred from Sequence Orthology more info
part_of BRISC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nuclear ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of nuclear ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of nuclear ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: BRISC and BRCA1-A complex member 2

Names: BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; brain and reproductive organ-expressed (TNFRSF1A modulator); brain and reproductive organ-expressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199270.2 → NP_954891.1 BRISC and BRCA1-A complex member 2

See identical proteins and their annotated locations for NP_954891.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q6P7Q1

UniProtKB/TrEMBL

A0A8I6A9B7, A6HA33

Related

ENSRNOP00000005855.5, ENSRNOT00000005855.6

Conserved Domains (1) summary

pfam06113
Location:8 → 333

BRE; Brain and reproductive organ-expressed protein (BRE)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

30089065..30467508 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262050.1 → XP_063118120.1 BRISC and BRCA1-A complex member 2 isoform X3
XM_039112461.2 → XP_038968389.1 BRISC and BRCA1-A complex member 2 isoform X1

UniProtKB/Swiss-Prot

Q6P7Q1

UniProtKB/TrEMBL

A0A8I6A9B7, A6HA33

Conserved Domains (1) summary

pfam06113
Location:8 → 333

BRE; Brain and reproductive organ-expressed protein (BRE)
XM_039112464.2 → XP_038968392.1 BRISC and BRCA1-A complex member 2 isoform X3

UniProtKB/TrEMBL

A0A8I5Y9T9
XM_006239802.4 → XP_006239864.1 BRISC and BRCA1-A complex member 2 isoform X1

See identical proteins and their annotated locations for XP_006239864.1

UniProtKB/Swiss-Prot

Q6P7Q1

UniProtKB/TrEMBL

A0A8I6A9B7, A6HA33

Conserved Domains (1) summary

pfam06113
Location:8 → 333

BRE; Brain and reproductive organ-expressed protein (BRE)
XM_039112465.2 → XP_038968393.1 BRISC and BRCA1-A complex member 2 isoform X4

Conserved Domains (1) summary

pfam06113
Location:1 → 195

BRE; Brain and reproductive organ-expressed protein (BRE)
XM_039112463.2 → XP_038968391.1 BRISC and BRCA1-A complex member 2 isoform X2

Conserved Domains (1) summary

pfam06113
Location:15 → 283

BRE; Brain and reproductive organ-expressed protein (BRE)
XM_039112468.2 → XP_038968396.1 BRISC and BRCA1-A complex member 2 isoform X4

Conserved Domains (1) summary

pfam06113
Location:1 → 195

BRE; Brain and reproductive organ-expressed protein (BRE)