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    Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamts9provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif, 9provided by RGD
    Primary source
    RGD:1306889
    See related
    EnsemblRapid:ENSRNOG00000023257 AllianceGenome:RGD:1306889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including circulatory system development; negative regulation of endothelial cell migration; and negative regulation of sprouting angiogenesis. Predicted to act upstream of or within camera-type eye development; positive regulation of melanocyte differentiation; and response to bacterium. Predicted to be located in cell surface; endoplasmic reticulum; and extracellular space. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 107.5), Lung (RPKM 85.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamts9 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126847726..127019924, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (125290633..125462988, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124660254..124860997, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene prickle planar cell polarity protein 2 Neighboring gene uncharacterized LOC134486613 Neighboring gene uncharacterized LOC134486616 Neighboring gene uncharacterized LOC102554570 Neighboring gene uncharacterized LOC120102343 Neighboring gene uncharacterized LOC102555978 Neighboring gene uncharacterized LOC134486615 Neighboring gene uncharacterized LOC120102344

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat. Reid MJ, et al. Neurosci Lett, 2009 Mar 20. PMID 19348733
    2. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. Somerville RP, et al. J Biol Chem, 2003 Mar 14. PMID 12514189
    3. Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase. Dancevic CM, et al. J Biol Chem, 2013 Dec 27. PMID 24220035, Free PMC Article
    4. ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Koo BH, et al. Am J Pathol, 2010 Mar. PMID 20093484, Free PMC Article
    5. Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Kern CB, et al. Matrix Biol, 2010 May. PMID 20096780, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study indicates that ADAMTS-9 expression is modulated in response to cerebral ischaemia in vivo
      Title: ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aorta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cornea development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of developmental pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 9
    Names
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429136.1 → NP_001416065.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IBC6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      126847726..127019924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286081.1 → XP_063142151.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X4

      UniProtKB/TrEMBL
      A6IBC6
      Related
      ENSRNOP00000079368.2, ENSRNOT00000114542.2

    2. XM_063286077.1 → XP_063142147.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X1

      Related
      ENSRNOP00000053878.4, ENSRNOT00000057045.4

    3. XM_063286078.1 → XP_063142148.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2

      UniProtKB/TrEMBL
      A6IBC6

    4. XM_063286080.1 → XP_063142150.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X3

      UniProtKB/TrEMBL
      A6IBC6

    RNA

    1. XR_010065646.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107877.1: Suppressed sequence

      Description
      NM_001107877.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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