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    Commd9 COMM domain containing 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Commd9provided by RGD
    Official Full Name
    COMM domain containing 9provided by RGD
    Primary source
    RGD:1307706
    See related
    EnsemblRapid:ENSRNOG00000004755 AllianceGenome:RGD:1307706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within cholesterol homeostasis. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Orthologous to human COMMD9 (COMM domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 291.0), Lung (RPKM 196.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Commd9 in Genome Data Viewer
    Location:
    3q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (108630903..108645427)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (88175909..88190427)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (91463612..91478097)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 6 Neighboring gene proline rich 5 like Neighboring gene uncharacterized LOC134486413 Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene uncharacterized LOC120101606

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel. Liu YF, et al. Am J Physiol Renal Physiol, 2013 Jul 1. PMID 23637203
    2. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article
    3. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Bartuzi P, et al. Nat Commun, 2016 Mar 11. PMID 26965651, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124765

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COMM domain-containing protein 9
    Names
    neuroprotective protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033692.2 → NP_001028864.1  COMM domain-containing protein 9 isoform 1

      See identical proteins and their annotated locations for NP_001028864.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      B3SVE6, F7F1B8, Q3MIE7
      Related
      ENSRNOP00000101505.1, ENSRNOT00000147312.1
      Conserved Domains (2) summary
      cd04757
      Location:90 → 197
      Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
      pfam03081
      Location:10 → 146
      Exo70; Exo70 exocyst complex subunit

    2. NM_001429952.1 → NP_001416881.1  COMM domain-containing protein 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNM9

    3. NM_001429953.1 → NP_001416882.1  COMM domain-containing protein 9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      B3SVE6, F7F1B8, Q3MIE7

    4. NM_001429954.1 → NP_001416883.1  COMM domain-containing protein 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNM9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      108630903..108645427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234637.5 → XP_006234699.1  COMM domain-containing protein 9 isoform X1

      Related
      ENSRNOP00000070509.3, ENSRNOT00000081984.3
      Conserved Domains (2) summary
      cd04757
      Location:90 → 197
      Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
      pfam03081
      Location:10 → 146
      Exo70; Exo70 exocyst complex subunit

    2. XM_063283308.1 → XP_063139378.1  COMM domain-containing protein 9 isoform X4

    3. XM_039104527.1 → XP_038960455.1  COMM domain-containing protein 9 isoform X2

      Conserved Domains (1) summary
      cd04757
      Location:48 → 155
      Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    4. XM_063283307.1 → XP_063139377.1  COMM domain-containing protein 9 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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