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    Tshz2 teashirt zinc finger homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tshz2provided by RGD
    Official Full Name
    teashirt zinc finger homeobox 2provided by RGD
    Primary source
    RGD:6490867
    See related
    EnsemblRapid:ENSRNOG00000048433 AllianceGenome:RGD:6490867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to act upstream of or within regulation of gene expression. Orthologous to human TSHZ2 (teashirt zinc finger homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 57.4), Heart (RPKM 56.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tshz2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (178824221..179271151)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (158405469..158666915)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (166469752..166748558)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486487 Neighboring gene uncharacterized LOC134486316 Neighboring gene uncharacterized LOC103691977 Neighboring gene uncharacterized LOC102556304 Neighboring gene uncharacterized LOC120101800 Neighboring gene uncharacterized LOC134486489 Neighboring gene uncharacterized LOC120101801 Neighboring gene uncharacterized LOC134486488 Neighboring gene uncharacterized LOC134486490 Neighboring gene uncharacterized LOC120101802 Neighboring gene U2 spliceosomal RNA Neighboring gene zinc finger protein 217 Neighboring gene uncharacterized LOC108350531

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Bedogni F, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615956, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    teashirt homolog 2
    Names
    teashirt homolog 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399744.2 → NP_001386673.1  teashirt homolog 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JXR9
      Related
      ENSRNOP00000100859.1, ENSRNOT00000149850.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      178824221..179271151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282975.1 → XP_063139045.1  teashirt homolog 2 isoform X4

      UniProtKB/TrEMBL
      A6JXR9, M0R6R4
      Related
      ENSRNOP00000101361.1, ENSRNOT00000131007.1

    2. XM_039106732.2 → XP_038962660.1  teashirt homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6JXR9
      Related
      ENSRNOP00000065119.3, ENSRNOT00000073788.3
      Conserved Domains (2) summary
      cd00086
      Location:861 → 929
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:241 → 263
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_063282974.1 → XP_063139044.1  teashirt homolog 2 isoform X3

      UniProtKB/TrEMBL
      A6JXR9

    4. XM_063282976.1 → XP_063139046.1  teashirt homolog 2 isoform X5

      UniProtKB/TrEMBL
      A6JXR9

    5. XM_039106734.2 → XP_038962662.1  teashirt homolog 2 isoform X2

      UniProtKB/TrEMBL
      A6JXR9
      Related
      ENSRNOP00000108262.1, ENSRNOT00000142962.1
      Conserved Domains (2) summary
      cd00086
      Location:835 → 903
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:215 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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