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Mef2c myocyte enhancer factor 2C [ Rattus norvegicus (Norway rat) ]

Gene ID: 499497, updated on 9-Dec-2024

Summary

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Symbol: Mef2cprovided by RGD
Full Name: myocyte enhancer factor 2Cprovided by RGD
Primary source: RGD:1563119
See related: EnsemblRapid:ENSRNOG00000033134 AllianceGenome:RGD:1563119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563119
Summary: Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including dentate gyrus development; response to ischemia; and transdifferentiation. Located in cytosol; nucleus; and sarcomere. Used to study myocardial infarction. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language. Orthologous to human MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 1118.3), Brain (RPKM 457.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Mef2c in Genome Data Viewer

Location:: 2q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (15708732..15871639)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (13973299..14136065)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (11658534..11822788)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c through an interaction with the FAK focal adhesion targeting (FAT) domain.
Title: FAK Forms a Complex with MEF2 to Couple Biomechanical Signaling to Transcription in Cardiomyocytes.
MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas MEF2C, despite its major role in cardiac morphogenesis and direct reprogramming, was dispensable for this process.
Title: Antagonistic regulation of cell-cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors.
Mef2c expression was sharply increased in compensating phase of right ventricular heart failure but lost in decompensation phase.
Title: A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension.
MEF2C expression in cardiac myocytes is inhibited by suppression of bone morphogenetic protein (BMP)2 expression levels.
Title: p300-mediated histone acetylation is essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.
while loss of delta-catenin does not alter the expression levels of endogenous Mef2, expression of Mef2 in neurons that are knocked down for delta-catenin promotes spine elimination.
Title: Mef2 promotes spine elimination in absence of δ-catenin.
a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17.
Title: A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression.
acute cocaine treatment of rats induced the expression of MEF2C in the striatum via activation of SIK1 and the phosphorylation of HDAC5
Title: Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5.
MEF2C depletion was accompanied by defective activation of S6K in response to pressure overload.
Title: MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice.
These novel data suggest that MEF2C activation by IGF-1 mediates the pro-hypertrophic effects of IGF-1 on cardiac gene expression.
Title: The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling.
physically associate through their DNA-binding domains to form a complex on the MYH6 promoter
Title: Physical interaction between TBX5 and MEF2C is required for early heart development.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133929 (e-PCR)
- UniSTS:217212

Mef2c (e-PCR), detects polymorphism
- UniSTS:265602

Mef2c (e-PCR), detects polymorphism
- UniSTS:265603

AU047435 (e-PCR)
- UniSTS:110512

G10647 (e-PCR)
- UniSTS:17885

AV011172 (e-PCR)
- UniSTS:165883

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISS Inferred from Sequence or Structural Similarity more info
enables minor groove of adenine-thymine-rich DNA binding	IEA Inferred from Electronic Annotation more info
enables minor groove of adenine-thymine-rich DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_negative_effect AMPA selective glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect AMPA selective glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in B cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_negative_effect NMDA selective glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect NMDA selective glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac ventricle formation	ISO Inferred from Sequence Orthology more info
involved_in cardiac ventricle formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis involved in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis involved in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell proliferation in bone marrow	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fluid shear stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to parathyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to parathyroid hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to trichostatin A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to trichostatin A	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in dentate gyrus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic heart tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation involved in renal tubule morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation involved in renal tubule morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in germinal center formation	ISO Inferred from Sequence Orthology more info
involved_in germinal center formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerulus morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in glomerulus morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in heart looping	ISS Inferred from Sequence or Structural Similarity more info
involved_in humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in myotube differentiation	IEA Inferred from Electronic Annotation more info
involved_in myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ossification	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ossification	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular associated smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in platelet formation	ISO Inferred from Sequence Orthology more info
involved_in platelet formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of alkaline phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alkaline phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavioral fear response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of skeletal muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in primary heart field specification	ISO Inferred from Sequence Orthology more info
involved_in primary heart field specification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of germinal center formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of germinal center formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in renal tubule morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in renal tubule morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ischemia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in secondary heart field specification	ISO Inferred from Sequence Orthology more info
involved_in secondary heart field specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in semaphorin-plexin signaling pathway involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in sinoatrial valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in sinoatrial valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in sympathetic neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myocyte-specific enhancer factor 2C

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399397.2 → NP_001386326.1 myocyte-specific enhancer factor 2C isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

A0A096MJY4

UniProtKB/TrEMBL

A0A096MKI4

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:107 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_001399399.2 → NP_001386328.1 myocyte-specific enhancer factor 2C isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A096MKI4

Conserved Domains (2) summary

COG5068
Location:1 → 245

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

15708732..15871639

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591163.3 → XP_017446652.1 myocyte-specific enhancer factor 2C isoform X1

UniProtKB/Swiss-Prot

A0A096MJY4

UniProtKB/TrEMBL

A0A096MKI4

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:107 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_063282317.1 → XP_063138387.1 myocyte-specific enhancer factor 2C isoform X6

UniProtKB/TrEMBL

A0A096MKI4
XM_039103394.2 → XP_038959322.1 myocyte-specific enhancer factor 2C isoform X2

UniProtKB/TrEMBL

A0A096MKI4

Related

ENSRNOP00000099728.1, ENSRNOT00000122974.1

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:96 → 150

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_063282316.1 → XP_063138386.1 myocyte-specific enhancer factor 2C isoform X4

UniProtKB/TrEMBL

A0A096MKI4

Related

ENSRNOP00000067970.3, ENSRNOT00000075931.4
XM_063282320.1 → XP_063138390.1 myocyte-specific enhancer factor 2C isoform X7

UniProtKB/TrEMBL

A0A096MJ29, A0A096MKI4, A6I4K4

Related

ENSRNOP00000067948.3, ENSRNOT00000076992.4
XM_063282321.1 → XP_063138391.1 myocyte-specific enhancer factor 2C isoform X9

UniProtKB/TrEMBL

A0A096MKI4
XM_063282322.1 → XP_063138392.1 myocyte-specific enhancer factor 2C isoform X11

UniProtKB/TrEMBL

A0A096MKI4
XM_063282319.1 → XP_063138389.1 myocyte-specific enhancer factor 2C isoform X6

UniProtKB/TrEMBL

A0A096MKI4

Related

ENSRNOP00000067963.2, ENSRNOT00000076481.4
XM_063282315.1 → XP_063138385.1 myocyte-specific enhancer factor 2C isoform X3

UniProtKB/TrEMBL

A0A096MKI4, A6I4K3
XM_039103397.2 → XP_038959325.1 myocyte-specific enhancer factor 2C isoform X5

UniProtKB/TrEMBL

A0A096MJ23, A0A096MKI4, A6I4J9

Conserved Domains (2) summary

COG5068
Location:1 → 245

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
XM_039103395.2 → XP_038959323.1 myocyte-specific enhancer factor 2C isoform X3

UniProtKB/TrEMBL

A0A096MKI4, A6I4K3

Conserved Domains (2) summary

COG5068
Location:1 → 245

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
XM_039103393.2 → XP_038959321.1 myocyte-specific enhancer factor 2C isoform X2

UniProtKB/TrEMBL

A0A096MKI4

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:96 → 150

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_039103401.2 → XP_038959329.1 myocyte-specific enhancer factor 2C isoform X8

UniProtKB/TrEMBL

A0A096MKI4

Related

ENSRNOP00000068094.3, ENSRNOT00000076136.4

Conserved Domains (1) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
XM_063282323.1 → XP_063138393.1 myocyte-specific enhancer factor 2C isoform X12

UniProtKB/TrEMBL

A0A096MKI4
XM_039103403.2 → XP_038959331.1 myocyte-specific enhancer factor 2C isoform X10

UniProtKB/TrEMBL

A0A096MJD9, A0A096MKI4

Conserved Domains (1) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
XM_039103399.2 → XP_038959327.1 myocyte-specific enhancer factor 2C isoform X7

UniProtKB/TrEMBL

A0A096MJ29, A0A096MKI4, A6I4K4

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:96 → 150

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_063282318.1 → XP_063138388.1 myocyte-specific enhancer factor 2C isoform X6

UniProtKB/TrEMBL

A0A096MKI4
XM_006231733.5 → XP_006231795.1 myocyte-specific enhancer factor 2C isoform X1

See identical proteins and their annotated locations for XP_006231795.1

UniProtKB/Swiss-Prot

A0A096MJY4

UniProtKB/TrEMBL

A0A096MKI4

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:107 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
XM_063282314.1 → XP_063138384.1 myocyte-specific enhancer factor 2C isoform X3

UniProtKB/TrEMBL

A0A096MKI4, A6I4K3