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    Ubap2l ubiquitin associated protein 2-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubap2lprovided by RGD
    Official Full Name
    ubiquitin associated protein 2-likeprovided by RGD
    Primary source
    RGD:1308707
    See related
    EnsemblRapid:ENSRNOG00000017990 AllianceGenome:RGD:1308707
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EP1; Atp8b2
    Summary
    Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; hematopoietic stem cell homeostasis; and positive regulation of stress granule assembly. Predicted to be part of PcG protein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBAP2L (ubiquitin associated protein 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 147.0), Adrenal (RPKM 127.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubap2l in Genome Data Viewer
    Location:
    2q34
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177736378..177791746, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175438703..175494085, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189334341..189400334, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485642 Neighboring gene uncharacterized LOC103691621 Neighboring gene HCLS1 associated protein X-1 Neighboring gene NS5A transactivated protein 4 Neighboring gene cilia and flagella associated protein 141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. Bordeleau ME, et al. Blood, 2014 Oct 9. PMID 25185265, Free PMC Article
    2. Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION. Ansari IU, et al. J Biol Chem, 2015 Sep 18. PMID 26240149, Free PMC Article
    3. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. Naz RK, et al. J Reprod Immunol, 2010 Jan. PMID 19945174, Free PMC Article
    4. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
    5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A. ATP8B1 and CDC50A were highly concentrated in ISG
      Title: Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated protein 2-like
    Names
    Atpase, class I, type 8B, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024798.2 → NP_001019969.2  ubiquitin-associated protein 2-like

      See identical proteins and their annotated locations for NP_001019969.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A0A8I6ARP3, A6J6I9, E9PTR4
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:516 → 543
      DUF3697; Ubiquitin-associated protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177736378..177791746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282147.1 → XP_063138217.1  ubiquitin-associated protein 2-like isoform X24

      UniProtKB/TrEMBL
      A0A8I6ARP3

    2. XM_063282140.1 → XP_063138210.1  ubiquitin-associated protein 2-like isoform X18

      UniProtKB/TrEMBL
      A0A8I6ARP3

    3. XM_063282157.1 → XP_063138227.1  ubiquitin-associated protein 2-like isoform X33

      UniProtKB/TrEMBL
      A0A0G2JYC6, A0A8I6ARP3, A6J6I8

    4. XM_063282155.1 → XP_063138225.1  ubiquitin-associated protein 2-like isoform X29

      UniProtKB/TrEMBL
      A0A8I6ARP3

    5. XM_063282150.1 → XP_063138220.1  ubiquitin-associated protein 2-like isoform X26

      UniProtKB/TrEMBL
      A0A8I6ARP3

    6. XM_063282148.1 → XP_063138218.1  ubiquitin-associated protein 2-like isoform X25

      UniProtKB/TrEMBL
      A0A8I6ARP3

    7. XM_063282156.1 → XP_063138226.1  ubiquitin-associated protein 2-like isoform X31

      UniProtKB/TrEMBL
      A0A8I6ARP3

    8. XM_063282149.1 → XP_063138219.1  ubiquitin-associated protein 2-like isoform X26

      UniProtKB/TrEMBL
      A0A8I6ARP3

    9. XM_063282146.1 → XP_063138216.1  ubiquitin-associated protein 2-like isoform X24

      UniProtKB/TrEMBL
      A0A8I6ARP3

    10. XM_063282142.1 → XP_063138212.1  ubiquitin-associated protein 2-like isoform X21

      UniProtKB/TrEMBL
      A0A8I6ARP3

    11. XM_039102685.2 → XP_038958613.1  ubiquitin-associated protein 2-like isoform X34

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496 → 523
      DUF3697; Ubiquitin-associated protein 2

    12. XM_039102681.2 → XP_038958609.1  ubiquitin-associated protein 2-like isoform X30

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496 → 523
      DUF3697; Ubiquitin-associated protein 2

    13. XM_039102683.2 → XP_038958611.1  ubiquitin-associated protein 2-like isoform X32

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507 → 534
      DUF3697; Ubiquitin-associated protein 2

    14. XM_063282141.1 → XP_063138211.1  ubiquitin-associated protein 2-like isoform X19

      UniProtKB/TrEMBL
      A0A8I6ARP3

    15. XM_039102667.2 → XP_038958595.1  ubiquitin-associated protein 2-like isoform X8

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:532 → 559
      DUF3697; Ubiquitin-associated protein 2

    16. XM_063282151.1 → XP_063138221.1  ubiquitin-associated protein 2-like isoform X27

      UniProtKB/TrEMBL
      A0A8I6ACU2, A0A8I6ARP3

    17. XM_063282152.1 → XP_063138222.1  ubiquitin-associated protein 2-like isoform X28

      UniProtKB/TrEMBL
      A0A8I6ARP3

    18. XM_063282138.1 → XP_063138208.1  ubiquitin-associated protein 2-like isoform X15

      UniProtKB/TrEMBL
      A0A8I6ARP3

    19. XM_063282137.1 → XP_063138207.1  ubiquitin-associated protein 2-like isoform X14

      UniProtKB/TrEMBL
      A0A8I6ARP3

    20. XM_063282136.1 → XP_063138206.1  ubiquitin-associated protein 2-like isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZUK2, A0A8I6ARP3

    21. XM_063282145.1 → XP_063138215.1  ubiquitin-associated protein 2-like isoform X22

      UniProtKB/TrEMBL
      A0A8I6ARP3

    22. XM_063282133.1 → XP_063138203.1  ubiquitin-associated protein 2-like isoform X10

      UniProtKB/TrEMBL
      A0A8I6ARP3

    23. XM_063282132.1 → XP_063138202.1  ubiquitin-associated protein 2-like isoform X9

      UniProtKB/TrEMBL
      A0A8I6ARP3

    24. XM_063282130.1 → XP_063138200.1  ubiquitin-associated protein 2-like isoform X6

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Related
      ENSRNOP00000082678.2, ENSRNOT00000117564.2

    25. XM_063282131.1 → XP_063138201.1  ubiquitin-associated protein 2-like isoform X9

      UniProtKB/TrEMBL
      A0A8I6ARP3

    26. XM_063282144.1 → XP_063138214.1  ubiquitin-associated protein 2-like isoform X22

      UniProtKB/TrEMBL
      A0A8I6ARP3

    27. XM_063282134.1 → XP_063138204.1  ubiquitin-associated protein 2-like isoform X11

      UniProtKB/TrEMBL
      A0A8I6ARP3

    28. XM_063282129.1 → XP_063138199.1  ubiquitin-associated protein 2-like isoform X6

      UniProtKB/TrEMBL
      A0A8I6ARP3

    29. XM_039102674.2 → XP_038958602.1  ubiquitin-associated protein 2-like isoform X17

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496 → 523
      DUF3697; Ubiquitin-associated protein 2

    30. XM_063282139.1 → XP_063138209.1  ubiquitin-associated protein 2-like isoform X16

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Related
      ENSRNOP00000091988.2, ENSRNOT00000116567.2

    31. XM_039102664.2 → XP_038958592.1  ubiquitin-associated protein 2-like isoform X5

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Related
      ENSRNOP00000096813.1, ENSRNOT00000101660.2
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:516 → 543
      DUF3697; Ubiquitin-associated protein 2

    32. XM_039102663.2 → XP_038958591.1  ubiquitin-associated protein 2-like isoform X4

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:521 → 548
      DUF3697; Ubiquitin-associated protein 2

    33. XM_039102677.2 → XP_038958605.1  ubiquitin-associated protein 2-like isoform X23

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507 → 534
      DUF3697; Ubiquitin-associated protein 2

    34. XM_063282135.1 → XP_063138205.1  ubiquitin-associated protein 2-like isoform X12

      UniProtKB/TrEMBL
      A0A8I6ARP3

    35. XM_063282128.1 → XP_063138198.1  ubiquitin-associated protein 2-like isoform X3

      UniProtKB/TrEMBL
      A0A8I6ARP3

    36. XM_039102666.2 → XP_038958594.1  ubiquitin-associated protein 2-like isoform X7

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:532 → 559
      DUF3697; Ubiquitin-associated protein 2

    37. XM_039102661.2 → XP_038958589.1  ubiquitin-associated protein 2-like isoform X2

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:50 → 87
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:532 → 559
      DUF3697; Ubiquitin-associated protein 2

    38. XM_063282127.1 → XP_063138197.1  ubiquitin-associated protein 2-like isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARP3

    39. XM_039102675.2 → XP_038958603.1  ubiquitin-associated protein 2-like isoform X20

      UniProtKB/TrEMBL
      A0A8I6ARP3
      Conserved Domains (2) summary
      cd14277
      Location:10 → 47
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:492 → 519
      DUF3697; Ubiquitin-associated protein 2

    40. XM_039102686.2 → XP_038958614.2  ubiquitin-associated protein 2-like isoform X37

      UniProtKB/TrEMBL
      A0A8I6ARP3

    41. XM_063282159.1 → XP_063138229.1  ubiquitin-associated protein 2-like isoform X36

      UniProtKB/TrEMBL
      A0A8I5ZWV5, A0A8I6ARP3
      Related
      ENSRNOP00000084271.1, ENSRNOT00000112048.2

    42. XM_063282165.1 → XP_063138235.1  ubiquitin-associated protein 2-like isoform X40

      UniProtKB/TrEMBL
      A0A8I6ARP3

    43. XM_063282162.1 → XP_063138232.1  ubiquitin-associated protein 2-like isoform X38

      UniProtKB/TrEMBL
      A0A8I6ARP3

    44. XM_063282163.1 → XP_063138233.1  ubiquitin-associated protein 2-like isoform X39

      UniProtKB/TrEMBL
      A0A8I6ARP3

    45. XM_063282158.1 → XP_063138228.1  ubiquitin-associated protein 2-like isoform X35

      UniProtKB/TrEMBL
      A0A8I6ARP3

    46. XM_063282161.1 → XP_063138231.1  ubiquitin-associated protein 2-like isoform X38

      UniProtKB/TrEMBL
      A0A8I6ARP3

    47. XM_063282160.1 → XP_063138230.1  ubiquitin-associated protein 2-like isoform X37

      UniProtKB/TrEMBL
      A0A8I6ARP3

    48. XM_063282164.1 → XP_063138234.1  ubiquitin-associated protein 2-like isoform X40

      UniProtKB/TrEMBL
      A0A8I6ARP3

    49. XM_063282166.1 → XP_063138236.1  ubiquitin-associated protein 2-like isoform X41

      UniProtKB/TrEMBL
      Q4V8A7
    Nucleotide Protein Strain
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