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    Palm3 paralemmin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100359592, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Palm3provided by RGD
    Official Full Name
    paralemmin 3provided by RGD
    Primary source
    RGD:2323602
    See related
    EnsemblRapid:ENSRNOG00000005729 AllianceGenome:RGD:2323602
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in Toll signaling pathway; negative regulation of cytokine-mediated signaling pathway; and response to lipopolysaccharide. Predicted to be located in membrane. Orthologous to human PALM3 (paralemmin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 34.9), Brain (RPKM 5.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Palm3 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41026757..41035217, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24121984..24126079, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25143464..25152275)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene relaxin 3 Neighboring gene interleukin 27 receptor subunit alpha Neighboring gene MISP family member 3 Neighboring gene microRNA 1199 Neighboring gene similar to human chromosome 19 open reading frame 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Paralemmin-3 augments lipopolysaccharide-induced acute lung injury with M1 macrophage polarization via the notch signaling pathway. Chen X, et al. Respir Physiol Neurobiol, 2024 Feb. PMID 38103708
    2. Paralemmin-3 contributes to lipopolysaccharide-induced inflammatory response and is involved in lipopolysaccharide-Toll-like receptor-4 signaling in alveolar macrophages. Chen XX, et al. Int J Mol Med, 2017 Dec. PMID 29039447
    3. A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3. Chen X, et al. Biochem Biophys Res Commun, 2011 Jan 28. PMID 21187075
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paralemmin-3 augments lipopolysaccharide-induced acute lung injury with M1 macrophage polarization via the notch signaling pathway.
      Title: Paralemmin-3 augments lipopolysaccharide-induced acute lung injury with M1 macrophage polarization via the notch signaling pathway.
    2. These results suggested that PALM3 contributes to the LPS-induced inflammatory response and participates in LPS-TLR4 signaling in Alveolar macrophages . These data may provide the basis for the development of novel targeted therapeutic strategies of treating acute lung injury.
      Title: Paralemmin-3 contributes to lipopolysaccharide-induced inflammatory response and is involved in lipopolysaccharide-Toll-like receptor-4 signaling in alveolar macrophages.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Toll signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Toll signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    paralemmin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41026757..41035217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002728582.7 → XP_002728628.3  paralemmin-3

      UniProtKB/TrEMBL
      A0A0G2JW79, A6IYB5, D4A1J3
      Related
      ENSRNOP00000007535.5, ENSRNOT00000007535.8
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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