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    Dtna dystrobrevin, alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307548, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dtnaprovided by RGD
    Official Full Name
    dystrobrevin, alphaprovided by RGD
    Primary source
    RGD:1561985
    See related
    EnsemblRapid:ENSRNOG00000016671 AllianceGenome:RGD:1561985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dtna-ps1; RGD1561985
    Summary
    Enables PDZ domain binding activity and phosphatase binding activity. Predicted to be involved in synaptic signaling. Located in axon and sarcolemma. Is extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to human DTNA (dystrobrevin alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 123.4), Brain (RPKM 87.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtna in Genome Data Viewer
    Location:
    18p12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (14862801..15218993)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (14687193..14944232)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (14544725..14671514)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene nucleolar protein 4 Neighboring gene cytochrome b5 type A, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120098123 Neighboring gene uncharacterized LOC134482916 Neighboring gene uncharacterized LOC120098122 Neighboring gene ribosomal protein L10, pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. WW and EF hand domains of dystrophin-family proteins mediate dystroglycan binding. Chung W, et al. Mol Cell Biol Res Commun, 1999 Sep-Dec. PMID 10662592
    2. Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum. Ueda H, et al. Neurosci Lett, 2000 Apr 7. PMID 10739890
    3. Dystrobrevin localization in photoreceptor axon terminals and at blood-ocular barrier sites. Ueda H, et al. Invest Ophthalmol Vis Sci, 2000 Nov. PMID 11053293
    4. Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Müller glial cells. Claudepierre T, et al. J Cell Sci, 2000 Oct. PMID 10984432
    5. Expression of the skeletal muscle dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto-Kakizaki rat. Mulvey C, et al. Eur J Cell Biol, 2005 Nov. PMID 16323284

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dystrobrevin alpha
    Names
    dystrobrevin alpha, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427105.1 → NP_001414034.1  dystrobrevin alpha

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      Related
      ENSRNOP00000098322.2, ENSRNOT00000120690.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      14862801..15218993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277418.1 → XP_063133488.1  dystrobrevin alpha isoform X1

    2. XM_063277429.1 → XP_063133499.1  dystrobrevin alpha isoform X7

    3. XM_063277438.1 → XP_063133508.1  dystrobrevin alpha isoform X12

    4. XM_063277432.1 → XP_063133502.1  dystrobrevin alpha isoform X9

      UniProtKB/TrEMBL
      A0A8I6AQU5

    5. XM_063277420.1 → XP_063133490.1  dystrobrevin alpha isoform X1

    6. XM_063277428.1 → XP_063133498.1  dystrobrevin alpha isoform X7

    7. XM_063277439.1 → XP_063133509.1  dystrobrevin alpha isoform X12

    8. XM_063277433.1 → XP_063133503.1  dystrobrevin alpha isoform X9

      UniProtKB/TrEMBL
      A0A8I6AQU5

    9. XM_063277436.1 → XP_063133506.1  dystrobrevin alpha isoform X10

    10. XM_063277441.1 → XP_063133511.1  dystrobrevin alpha isoform X15

    11. XM_039097220.2 → XP_038953148.1  dystrobrevin alpha isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQM2, A6J2I4
      Related
      ENSRNOP00000080605.1, ENSRNOT00000112648.3
      Conserved Domains (3) summary
      COG0419
      Location:422 → 557
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    12. XM_063277425.1 → XP_063133495.1  dystrobrevin alpha isoform X2

    13. XM_039097225.2 → XP_038953153.1  dystrobrevin alpha isoform X7

      Conserved Domains (3) summary
      COG0419
      Location:365 → 500
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    14. XM_063277435.1 → XP_063133505.1  dystrobrevin alpha isoform X10

    15. XM_063277421.1 → XP_063133491.1  dystrobrevin alpha isoform X1

    16. XM_063277424.1 → XP_063133494.1  dystrobrevin alpha isoform X1

    17. XM_063277434.1 → XP_063133504.1  dystrobrevin alpha isoform X9

      UniProtKB/TrEMBL
      A0A8I6AQU5

    18. XM_039097218.2 → XP_038953146.1  dystrobrevin alpha isoform X1

      Conserved Domains (3) summary
      COG0419
      Location:422 → 557
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    19. XM_039097226.2 → XP_038953154.1  dystrobrevin alpha isoform X9

      UniProtKB/TrEMBL
      A0A8I6AQU5
      Conserved Domains (4) summary
      COG0419
      Location:365 → 494
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl09111
      Location:438 → 576
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    20. XM_063277427.1 → XP_063133497.1  dystrobrevin alpha isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQM2

    21. XM_039097235.2 → XP_038953163.1  dystrobrevin alpha isoform X6

      UniProtKB/TrEMBL
      A6J2I4
      Conserved Domains (4) summary
      COG1340
      Location:466 → 547
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      pfam10186
      Location:417 → 591
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    22. XM_063277426.1 → XP_063133496.1  dystrobrevin alpha isoform X3

      Related
      ENSRNOP00000096468.2, ENSRNOT00000097179.2

    23. XM_063277431.1 → XP_063133501.1  dystrobrevin alpha isoform X8

    24. XM_039097234.2 → XP_038953162.1  dystrobrevin alpha isoform X5

      UniProtKB/TrEMBL
      A6J2I4
      Related
      ENSRNOP00000103129.1, ENSRNOT00000128772.1
      Conserved Domains (4) summary
      COG0419
      Location:422 → 551
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl39057
      Location:465 → 655
      MS_channel; Mechanosensitive ion channel

    25. XM_039097231.2 → XP_038953159.1  dystrobrevin alpha isoform X13

      UniProtKB/TrEMBL
      A6J2I5
      Conserved Domains (4) summary
      COG1340
      Location:409 → 490
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl39057
      Location:407 → 597
      MS_channel; Mechanosensitive ion channel

    26. XM_039097227.2 → XP_038953155.1  dystrobrevin alpha isoform X11

      UniProtKB/TrEMBL
      A6J2I5
      Related
      ENSRNOP00000104545.1, ENSRNOT00000127932.1
      Conserved Domains (3) summary
      COG0419
      Location:365 → 500
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    27. XM_017601081.3 → XP_017456570.2  dystrobrevin alpha isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZKV1
      Related
      ENSRNOP00000042067.6, ENSRNOT00000045224.9
      Conserved Domains (3) summary
      COG0419
      Location:365 → 500
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    28. XM_017601083.3 → XP_017456572.2  dystrobrevin alpha isoform X16

      UniProtKB/TrEMBL
      A0A8I6APF7
      Related
      ENSRNOP00000095584.1, ENSRNOT00000114052.2
      Conserved Domains (2) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    29. XM_063277437.1 → XP_063133507.1  dystrobrevin alpha isoform X12

    30. XM_063277423.1 → XP_063133493.1  dystrobrevin alpha isoform X1

    31. XM_063277419.1 → XP_063133489.1  dystrobrevin alpha isoform X1

    32. XM_063277430.1 → XP_063133500.1  dystrobrevin alpha isoform X7

    33. XM_063277440.1 → XP_063133510.1  dystrobrevin alpha isoform X14

    34. XM_063277442.1 → XP_063133512.1  dystrobrevin alpha isoform X16

      UniProtKB/TrEMBL
      A0A8I6APF7
    Nucleotide Protein Strain
    Heading Accession and Version

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