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    Cntrob centrobin, centriole duplication and spindle assembly protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303240, updated on 9-Dec-2024

    Summary

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    Symbol
    Cntrobprovided by RGD
    Full Name
    centrobin, centriole duplication and spindle assembly proteinprovided by RGD
    Primary source
    RGD:1307488
    See related
    EnsemblRapid:ENSRNOG00000008270 AllianceGenome:RGD:1307488
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lip8; RGD1307488
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be involved in centriole replication; centrosome separation; and mitotic cytokinetic process. Predicted to be active in centriole and centrosome. Used to study male infertility and male infertility due to acephalic spermatozoa. Orthologous to human CNTROB (centrobin, centriole duplication and spindle assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 42.5), Testes (RPKM 21.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cntrob in Genome Data Viewer
    Location:
    10q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54521338..54546569, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54022523..54047793, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55901929..55927121, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase, type B Neighboring gene guanylate cyclase 2D, retinal Neighboring gene U6 spliceosomal RNA Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3 Neighboring gene ring finger protein 227

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of full-length centrobin rescues limb malformation but not male fertility of the hypodactylous (hd) rats. Liška F, et al. PLoS One, 2013. PMID 23577170, Free PMC Article
    2. Centrobin-tubulin interaction is required for centriole elongation and stability. Gudi R, et al. J Cell Biol, 2011 May 16. PMID 21576394, Free PMC Article
    3. Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. Zou C, et al. J Cell Biol, 2005 Nov 7. PMID 16275750, Free PMC Article
    4. Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus. Liska F, et al. Biol Reprod, 2009 Dec. PMID 19710508, Free PMC Article
    5. CEP295 interacts with microtubules and is required for centriole elongation. Chang CW, et al. J Cell Sci, 2016 Jul 1. PMID 27185865, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. centrobin is essential for normal patterning of the limb autopod
      Title: Overexpression of full-length centrobin rescues limb malformation but not male fertility of the hypodactylous (hd) rats.
    2. Cntrob may represent a novel candidate gene for presently unexplained hereditary forms of teratozoospermia and the "easily decapitated sperm syndrome" in humans.
      Title: Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrobin
    Names
    LYST-interacting protein 8
    centrobin, centrosomal BRCA2 interacting protein
    centrobin-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134645.1 → NP_001128117.1  centrobin

      See identical proteins and their annotated locations for NP_001128117.1

      Status: PROVISIONAL

      Source sequence(s)
      EF532342
      UniProtKB/TrEMBL
      B2BKY8, B2BKZ0
      Related
      ENSRNOP00000011185.5, ENSRNOT00000011185.9
      Conserved Domains (2) summary
      PHA03247
      Location:568 → 766
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:179 → 551
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54521338..54546569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767825.4 → XP_008766047.1  centrobin isoform X2

      UniProtKB/TrEMBL
      B2BKZ0
      Conserved Domains (2) summary
      PHA03247
      Location:469 → 667
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:80 → 452
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039085975.2 → XP_038941903.1  centrobin isoform X1

      UniProtKB/TrEMBL
      B2BKZ0
      Conserved Domains (2) summary
      PHA03247
      Location:568 → 766
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:179 → 551
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_039085976.2 → XP_038941904.1  centrobin isoform X2

      UniProtKB/TrEMBL
      B2BKZ0
      Conserved Domains (2) summary
      PHA03247
      Location:469 → 667
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:80 → 452
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_039085978.2 → XP_038941906.1  centrobin isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:285 → 483
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:1 → 283
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_063269027.1 → XP_063125097.1  centrobin isoform X3

    6. XM_063269026.1 → XP_063125096.1  centrobin isoform X3

    7. XM_039085977.2 → XP_038941905.1  centrobin isoform X4

      Conserved Domains (1) summary
      COG1196
      Location:179 → 551
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_005489823.2 RNA Sequence

    2. XR_005489822.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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