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    Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287101, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pkmyt1provided by RGD
    Official Full Name
    protein kinase, membrane associated tyrosine/threonine 1provided by RGD
    Primary source
    RGD:1305434
    See related
    EnsemblRapid:ENSRNOG00000003657 AllianceGenome:RGD:1305434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305434
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of G2/MI transition of meiotic cell cycle. Predicted to be located in Golgi apparatus; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 44.4), Thymus (RPKM 39.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pkmyt1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13252805..13263584)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12748221..12758995)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13061077..13072277)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene claudin 9 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene glycine rich extracellular protein 1 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene RIKEN cDNA 9530082P21 gene like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. Oh JS, et al. J Cell Biol, 2010 Jan 25. PMID 20083600, Free PMC Article
    2. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. Booher RN, et al. J Biol Chem, 1997 Aug 29. PMID 9268380
    3. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
    NP_001099236.1
    XP_017452548.1
    XP_063124618.1
    XP_063124619.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105766.1 → NP_001099236.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

      See identical proteins and their annotated locations for NP_001099236.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HCL6, B5DFC5, G3V6G8
      Conserved Domains (2) summary
      smart00220
      Location:101 → 350
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14050
      Location:99 → 348
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13252805..13263584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597059.3 → XP_017452548.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

      UniProtKB/TrEMBL
      A6HCL6, B5DFC5, G3V6G8
      Related
      ENSRNOP00000004936.4, ENSRNOT00000004936.8
      Conserved Domains (2) summary
      smart00220
      Location:101 → 350
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14050
      Location:99 → 348
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

    2. XM_063268549.1 → XP_063124619.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    3. XM_063268548.1 → XP_063124618.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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