Alox15b arachidonate 15-lipoxygenase, type B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alox15bprovided by RGD
Official Full Name: arachidonate 15-lipoxygenase, type Bprovided by RGD
Primary source: RGD:628809
See related: EnsemblRapid:ENSRNOG00000007778 AllianceGenome:RGD:628809
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables arachidonate 15-lipoxygenase activity. Involved in arachidonate metabolic process; hepoxilin biosynthetic process; and lipoxygenase pathway. Predicted to be located in several cellular components, including adherens junction; cytosol; and focal adhesion. Orthologous to human ALOX15B (arachidonate 15-lipoxygenase type B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 20.0), Kidney (RPKM 17.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54391331..54400648, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53892496..53901812, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55773748..55783489, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Consistent with the decreases in the 15-LOX metabolites, expression levels of the genes that encode the 15-LOXs, Alox15 and Alox15b, were largely reduced in Olmsted syndrome model rats.
Title: Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats.
Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension.
Title: Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
Hypoxia promotes pulmonary artery smooth muscle cell proliferation and survival, contributing to pulmonary vascular medial hypertrophy, which is likely to be mediated via the PDGF-BB/15-LO-2/15-HETE pathway.
Title: Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition.
12/15-LO activation has roles in macrophage and vascular smooth muscle cell oxidant stress and inflammation
Title: Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.

Submit: New GeneRIF Correction

General gene information

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Markers

Alox8 (e-PCR), detects polymorphism
- UniSTS:546650

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate 15-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate 15-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate 15-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonate 15-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate 8(S)-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonate 8(S)-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables linoleate 13S-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables linoleate 13S-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables linoleate 9S-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables linoleate 9S-lipoxygenase activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cannabinoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cannabinoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cannabinoid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocannabinoid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endocannabinoid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endocannabinoid signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepoxilin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hepoxilin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in linoleic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid oxidation	IEA Inferred from Electronic Annotation more info
involved_in lipoxin A4 biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipoxin A4 biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipoxin A4 biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxygenase pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lipoxygenase pathway	IEA Inferred from Electronic Annotation more info
involved_in lipoxygenase pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: polyunsaturated fatty acid lipoxygenase ALOX15B

Names: 15-LOX-2; 15-LOX-B; 15-lipoxygenase 2; arachidonate 15-lipoxygenase B; arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; linoleate 13-lipoxygenase 15-LOb

NP_695213.1

EC 1.13.11.33

XP_063124558.1

EC 1.13.11.33

XP_063124559.1

EC 1.13.11.33

XP_063124560.1

EC 1.13.11.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153301.2 → NP_695213.1 polyunsaturated fatty acid lipoxygenase ALOX15B

See identical proteins and their annotated locations for NP_695213.1

Status: PROVISIONAL

Source sequence(s)

AF415240

UniProtKB/Swiss-Prot

Q8K4F2

UniProtKB/TrEMBL

A6HFP2, G3V6Z8

Related

ENSRNOP00000010416.5, ENSRNOT00000010415.8

Conserved Domains (2) summary

cd01753
Location:2 → 122

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:230 → 668

Lipoxygenase; Lipoxygenase