Glrx3 glutaredoxin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glrx3provided by RGD
Official Full Name: glutaredoxin 3provided by RGD
Primary source: RGD:69414
See related: EnsemblRapid:ENSRNOG00000016227 AllianceGenome:RGD:69414
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PICOT; Txnl2
Summary: Enables protein kinase C binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; cell redox homeostasis; and negative regulation of cardiac muscle hypertrophy. Located in dendrite. Orthologous to human GLRX3 (glutaredoxin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 423.3), Thymus (RPKM 317.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (201671410..201701722)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (192241707..192272012)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (209768696..209799912)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that PICOT inhibits cardiac hypertrophy largely by negatively regulating calcineurin-NFAT signaling via disruption of the MLP-calcineurin interaction.
Title: PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

BE117517 (e-PCR)
- UniSTS:248695

BE113509 (e-PCR)
- UniSTS:246689

NoName (e-PCR)
- UniSTS:234962

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in [2Fe-2S] cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in [2Fe-2S] cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by iron-sulfur cluster transfer	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by iron-sulfur cluster transfer	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of iron-sulfur cluster assembly complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutaredoxin-3

Names: PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; thioredoxin-like 2; thioredoxin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032614.2 → NP_116003.2 glutaredoxin-3

Status: PROVISIONAL

Source sequence(s)

BC086381

UniProtKB/Swiss-Prot

Q5RK11, Q9JLZ1

UniProtKB/TrEMBL

A0A8I6AG27, A6HX85

Related

ENSRNOP00000022406.5, ENSRNOT00000022406.8

Conserved Domains (2) summary

cd02984
Location:20 → 115

TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...

cd03028
Location:139 → 227

GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

201671410..201701722

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088751.2 → XP_038944679.1 glutaredoxin-3 isoform X2

Conserved Domains (2) summary

cd02984
Location:20 → 115

TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...

cd03028
Location:139 → 227

GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
XM_039088750.2 → XP_038944678.1 glutaredoxin-3 isoform X1

UniProtKB/TrEMBL

A0A0G2K5P8, A0A8I5ZN19

Related

ENSRNOP00000073509.1, ENSRNOT00000083316.3

Conserved Domains (2) summary

cd03028
Location:89 → 177

GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

PTZ00062
Location:3 → 182

PTZ00062; glutaredoxin; Provisional
XM_063272117.1 → XP_063128187.1 glutaredoxin-3 isoform X3

UniProtKB/TrEMBL

A6HX87