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    Ptprk protein tyrosine phosphatase, receptor type, K [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360302, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptprkprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Kprovided by RGD
    Primary source
    RGD:619706
    See related
    EnsemblRapid:ENSRNOG00000047605 AllianceGenome:RGD:619706
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rptpk
    Summary
    Predicted to enable several functions, including beta-catenin binding activity; gamma-catenin binding activity; and protein tyrosine phosphatase activity. Involved in T cell differentiation; cell adhesion; and neuron projection development. Predicted to be located in several cellular components, including leading edge membrane; neuronal cell body; and photoreceptor outer segment. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 161.2), Lung (RPKM 125.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptprk in Genome Data Viewer
    Location:
    1p12
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (18557091..19056297, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (16738896..17236687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (17445052..18058266, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene thymocyte selection associated Neighboring gene antagonist of mitotic exit network 1, pseudogene 1 Neighboring gene autophagy related 4B, cysteine peptidase, pseudogene 1 Neighboring gene uncharacterized LOC120098804 Neighboring gene uncharacterized LOC120098806 Neighboring gene uncharacterized LOC134484965 Neighboring gene uncharacterized LOC120098805 Neighboring gene uncharacterized LOC134484966 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 4 Neighboring gene RuvB-like AAA ATPase 1, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in leading edge membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase kappa
    Names
    protein tyrosine phosphatase, receptor type, K, extracellular region
    receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK)
    NP_001025073.2
    XP_063121937.1
    XP_063121938.1
    XP_063121941.1
    XP_063121942.1
    XP_063121945.1
    XP_063121947.1
    XP_063121950.1
    XP_063121954.1
    XP_063121957.1
    XP_063121959.1
    XP_063121968.1
    XP_063121975.1
    XP_063121976.1
    XP_063121977.1
    XP_063121983.1
    XP_063121989.1
    XP_063121997.1
    XP_063122006.1
    XP_063122009.1
    XP_063122013.1
    XP_063122014.1
    XP_063122015.1
    XP_063122018.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029902.2NP_001025073.2  receptor-type tyrosine-protein phosphatase kappa precursor

      See identical proteins and their annotated locations for NP_001025073.2

      Status: PROVISIONAL

      Source sequence(s)
      AB297790
      UniProtKB/TrEMBL
      A5I9F0, F1LPL4
      Conserved Domains (9) summary
      cd06263
      Location:35191
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:31191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:8861140
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:201287
      IG_like; Immunoglobulin like
      cd00047
      Location:9131140
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:487588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:293371
      fn3; Fibronectin type III domain
      pfam00102
      Location:12001434
      Y_phosphatase; Protein-tyrosine phosphatase
      cl11960
      Location:203283
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      18557091..19056297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265927.1XP_063121997.1  receptor-type tyrosine-protein phosphatase kappa isoform X17

    2. XM_063265913.1XP_063121983.1  receptor-type tyrosine-protein phosphatase kappa isoform X15

    3. XM_063265905.1XP_063121975.1  receptor-type tyrosine-protein phosphatase kappa isoform X12

    4. XM_063265948.1XP_063122018.1  receptor-type tyrosine-protein phosphatase kappa isoform X23

    5. XM_063265880.1XP_063121950.1  receptor-type tyrosine-protein phosphatase kappa isoform X7

    6. XM_063265868.1XP_063121938.1  receptor-type tyrosine-protein phosphatase kappa isoform X2

    7. XM_063265919.1XP_063121989.1  receptor-type tyrosine-protein phosphatase kappa isoform X16

    8. XM_063265907.1XP_063121977.1  receptor-type tyrosine-protein phosphatase kappa isoform X14

    9. XM_063265906.1XP_063121976.1  receptor-type tyrosine-protein phosphatase kappa isoform X13

    10. XM_063265898.1XP_063121968.1  receptor-type tyrosine-protein phosphatase kappa isoform X11

      Related
      ENSRNOP00000105620.1, ENSRNOT00000150254.1
    11. XM_063265887.1XP_063121957.1  receptor-type tyrosine-protein phosphatase kappa isoform X9

    12. XM_063265945.1XP_063122015.1  receptor-type tyrosine-protein phosphatase kappa isoform X22

      Related
      ENSRNOP00000108431.1, ENSRNOT00000156515.1
    13. XM_063265877.1XP_063121947.1  receptor-type tyrosine-protein phosphatase kappa isoform X6

      Related
      ENSRNOP00000100835.1, ENSRNOT00000121655.1
    14. XM_063265889.1XP_063121959.1  receptor-type tyrosine-protein phosphatase kappa isoform X10

      Related
      ENSRNOP00000107475.1, ENSRNOT00000121569.1
    15. XM_063265884.1XP_063121954.1  receptor-type tyrosine-protein phosphatase kappa isoform X8

    16. XM_063265875.1XP_063121945.1  receptor-type tyrosine-protein phosphatase kappa isoform X5

    17. XM_063265871.1XP_063121941.1  receptor-type tyrosine-protein phosphatase kappa isoform X3

      Related
      ENSRNOP00000104699.1, ENSRNOT00000132092.1
    18. XM_063265872.1XP_063121942.1  receptor-type tyrosine-protein phosphatase kappa isoform X4

    19. XM_063265867.1XP_063121937.1  receptor-type tyrosine-protein phosphatase kappa isoform X1

      Related
      ENSRNOP00000099423.1, ENSRNOT00000151000.1
    20. XM_063265943.1XP_063122013.1  receptor-type tyrosine-protein phosphatase kappa isoform X20

      UniProtKB/TrEMBL
      A6JPF0
    21. XM_063265939.1XP_063122009.1  receptor-type tyrosine-protein phosphatase kappa isoform X19

      UniProtKB/TrEMBL
      A6JPF0
    22. XM_063265936.1XP_063122006.1  receptor-type tyrosine-protein phosphatase kappa isoform X18

      UniProtKB/TrEMBL
      A6JPF0
    23. XM_063265944.1XP_063122014.1  receptor-type tyrosine-protein phosphatase kappa isoform X21