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    Dcaf12 DDB1 and CUL4 associated factor 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682812, updated on 4-Jan-2025

    Summary

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    Symbol
    Dcaf12provided by RGD
    Full Name
    DDB1 and CUL4 associated factor 12provided by RGD
    Primary source
    RGD:1594034
    See related
    EnsemblRapid:ENSRNOG00000050790 AllianceGenome:RGD:1594034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in T cell activation and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in centrosome. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytosol. Orthologous to human DCAF12 (DDB1 and CUL4 associated factor 12). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 206.1), Testes (RPKM 182.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcaf12 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61256353..61278155, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56460418..56482171, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (57666781..57685360, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated protein 2 Neighboring gene small nucleolar RNA SNORD121A Neighboring gene ribosomal protein S13 like 1 Neighboring gene uncharacterized LOC134486930 Neighboring gene uncharacterized LOC120103061

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel centrosome protein, TCC52, is a cancer-testis antigen. Li S, et al. Cancer Sci, 2008 Nov. PMID 18957058, Free PMC Article
    2. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 12
    Names
    DDB1- and CUL4-associated factor 12-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427703.1 → NP_001414632.1  DDB1- and CUL4-associated factor 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      M0RC41
      Related
      ENSRNOP00000067148.3, ENSRNOT00000074796.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      61256353..61278155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111403.2 → XP_038967331.1  DDB1- and CUL4-associated factor 12 isoform X1

      UniProtKB/TrEMBL
      M0RC41
      Conserved Domains (2) summary
      sd00039
      Location:144 → 180
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:85 → 279
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039111405.2 → XP_038967333.1  DDB1- and CUL4-associated factor 12 isoform X3

      Related
      ENSRNOP00000099462.1, ENSRNOT00000148409.1
      Conserved Domains (2) summary
      sd00039
      Location:120 → 156
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:61 → 255
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_039111406.2 → XP_038967334.1  DDB1- and CUL4-associated factor 12 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A3M3
      Related
      ENSRNOP00000085590.1, ENSRNOT00000119656.2
      Conserved Domains (2) summary
      sd00039
      Location:119 → 155
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:60 → 254
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_063288403.1 → XP_063144473.1  DDB1- and CUL4-associated factor 12 isoform X6

    5. XM_039111404.2 → XP_038967332.1  DDB1- and CUL4-associated factor 12 isoform X2

      Related
      ENSRNOP00000108412.1, ENSRNOT00000147854.1
      Conserved Domains (2) summary
      sd00039
      Location:138 → 174
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:79 → 273
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_063288402.1 → XP_063144472.1  DDB1- and CUL4-associated factor 12 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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