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    dsx doublesex [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40940, updated on 2-Nov-2024

    Summary

    Official Symbol
    dsxprovided by FlyBase
    Official Full Name
    doublesexprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000504
    Locus tag
    Dmel_CG11094
    See related
    AllianceGenome:FB:FBgn0000504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11094; Dmdsx; Dmel\CG11094; Dsx; DSX; dsxF; DSXF; dsxM; DSXM; Hr; ix-62c
    Summary
    Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and zinc ion binding activity. Involved in axon midline choice point recognition; imaginal disc-derived genitalia development; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adult doublesex neurons; adult muscle cell; imaginal disc; organism subdivision; and sense organ. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See dsx in Genome Data Viewer
    Location:
    84E5-84E6; 3-48 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7924323..7967408, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3750045..3793130, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA : MeU2-C41 Neighboring gene uncharacterized protein Neighboring gene lodestar Neighboring gene CD98 heavy chain Neighboring gene Seminal fluid protein 84E Neighboring gene Os-C

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: c7947820-7947788 mobile_element_type = transposon:gtwin{}1846

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in courtship behavior NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in female analia development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in female sex differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in female somatic sex determination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in genital disc development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived female genitalia development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in imaginal disc-derived female genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived male genitalia development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in male analia development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in male courtship behavior TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in male courtship behavior, veined wing generated song production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in male sex differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of developmental pigmentation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sex comb development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sex determination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sex-specific pigmentation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in somatic sex determination TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    doublesex
    Names
    CG11094-PA
    CG11094-PB
    CG11094-PC
    CG11094-PD
    CG11094-PE
    CG11094-PF
    CG11094-PG
    double sex
    dsx-PA
    dsx-PB
    dsx-PC
    dsx-PD
    dsx-PE
    dsx-PF
    dsx-PG
    hermaphrodite
    intersex-62c

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7924323..7967408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169202.1NP_731197.1  doublesex, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731197.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23022, P23023, Q0KIA7, Q95TA5, Q9VHY0
      UniProtKB/TrEMBL
      A0A0B4KFS4
      Related
      FBpp0081256, FBtr0081759
      Conserved Domains (2) summary
      pfam00751
      Location:4186
      DM; DM DNA binding domain
      pfam08828
      Location:353404
      DSX_dimer; Doublesex dimerization domain
    2. NM_001275424.1NP_001262353.1  doublesex, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGR7
      Conserved Domains (2) summary
      pfam00751
      Location:4186
      DM; DM DNA binding domain
      pfam08828
      Location:353404
      DSX_dimer; Doublesex dimerization domain
    3. NM_001275423.1NP_001262352.1  doublesex, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262352.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23022, P23023, Q0KIA7, Q95TA5, Q9VHY0
      UniProtKB/TrEMBL
      A0A0B4KFS4
      Conserved Domains (2) summary
      pfam00751
      Location:4186
      DM; DM DNA binding domain
      pfam08828
      Location:353404
      DSX_dimer; Doublesex dimerization domain
    4. NM_001300291.1NP_001287220.1  doublesex, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGS9
      Conserved Domains (2) summary
      pfam00751
      Location:4186
      DM; DM DNA binding domain
      pfam08828
      Location:353412
      DSX_dimer; Doublesex dimerization domain
    5. NM_169203.2NP_731198.1  doublesex, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGS9
      Related
      FBpp0081257
      Conserved Domains (2) summary
      pfam00751
      Location:4186
      DM; DM DNA binding domain
      pfam08828
      Location:353412
      DSX_dimer; Doublesex dimerization domain
    6. NM_001426709.1NP_001413640.1  doublesex, isoform G [Drosophila melanogaster]

      Status: REVIEWED

    7. NM_079548.5NP_524272.4  doublesex, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524272.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGS9
      Related
      FBpp0081258
      Conserved Domains (2) summary
      pfam00751
      Location:4186
      DM; DM DNA binding domain
      pfam08828
      Location:353412
      DSX_dimer; Doublesex dimerization domain