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    Zfp72 zinc finger protein 72 [ Mus musculus (house mouse) ]

    Gene ID: 238722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp72provided by MGI
    Official Full Name
    zinc finger protein 72provided by MGI
    Primary source
    MGI:MGI:3033356
    See related
    Ensembl:ENSMUSG00000069184 AllianceGenome:MGI:3033356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp74
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to several human genes including ZNF429 (zinc finger protein 429) and ZNF678 (zinc finger protein 678). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 1.1), cortex adult (RPKM 0.7) and 22 other tissues See more
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    Genomic context

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    See Zfp72 in Genome Data Viewer
    Location:
    13 C1; 13 40.23 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74517443..74538948, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74369321..74390861, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase complex, subunit A, flavoprotein (Fp) Neighboring gene STARR-positive B cell enhancer ABC_E10800 Neighboring gene coiled-coil domain containing 127 Neighboring gene leucine rich repeat containing 14B Neighboring gene STARR-seq mESC enhancer starr_35006 Neighboring gene BCL2-like 13 (apoptosis facilitator) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7251 Neighboring gene STARR-seq mESC enhancer starr_35008 Neighboring gene ferritin light polypeptide 1, pseudogene 1 Neighboring gene microRNA 692-3 Neighboring gene predicted gene, 41004

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    3. A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci. Juriloff DM, et al. Birth Defects Res A Clin Mol Teratol, 2004 Aug. PMID 15329828
    4. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 72
    Names
    zinc finger protein 74

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374038.3 → NP_001360967.2  zinc finger protein 72 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009486
      Consensus CDS
      CCDS36732.1

    2. NM_001426443.1 → NP_001413372.1  zinc finger protein 72 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009486

    3. NM_001426445.1 → NP_001413374.1  zinc finger protein 72 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT009486

    4. NM_001426446.1 → NP_001413375.1  zinc finger protein 72 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT009486
      UniProtKB/TrEMBL
      A0A1Y7VM41, Q0VFY0
      Related
      ENSMUSP00000152502.3, ENSMUST00000223163.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      74517443..74538948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081680.2: Suppressed sequence

      Description
      NM_001081680.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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