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    Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 [ Mus musculus (house mouse) ]

    Gene ID: 56258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnrnph2provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein H2provided by MGI
    Primary source
    MGI:MGI:1201779
    See related
    Ensembl:ENSMUSG00000045427 AllianceGenome:MGI:1201779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H'; Ftp3; Ftp-3; HNRNP; Hnrph2; DXHXS1271E
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in cytosol. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm and postsynaptic density. Is expressed in brain; heart; olfactory epithelium; and spinal cord. Used to study syndromic X-linked intellectual developmental disorder bain type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual developmental disorder bain type. Orthologous to human HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 40.2), liver E14 (RPKM 35.3) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hnrnph2 in Genome Data Viewer
    Location:
    X E3; X 56.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133501928..133507809)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134601179..134607060)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47960 Neighboring gene ribosomal protein L36A Neighboring gene galactosidase, alpha Neighboring gene STARR-positive B cell enhancer mm9_chrX:131135522-131135823 Neighboring gene predicted gene 7855 Neighboring gene predicted gene, 19502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene. Hamada T, et al. J Physiol Sci, 2015 Jul. PMID 25846207, Free PMC Article
    2. Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci. Oeltjen JC, et al. Mamm Genome, 1995 May. PMID 7626884
    3. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. Ruan QT, et al. J Neurosci, 2020 Jan 2. PMID 31704785, Free PMC Article
    4. Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Oeltjen JC, et al. Genome Res, 1997 Apr. PMID 9110171
    5. Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis. Loeb CR, et al. J Biol Chem, 2006 Sep 22. PMID 16798735

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.
      Title: A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.
    2. hnRNP C and hnRNP H bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2).
      Title: Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein H2
    Names
    heterogeneous nuclear ribonucleoprotein H'
    hnRNP H'
    hnRNP H2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313716.1 → NP_001300645.1  heterogeneous nuclear ribonucleoprotein H2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AI853236, AK077716, BB844564, BX004852
      Consensus CDS
      CCDS30397.1
      UniProtKB/Swiss-Prot
      P70333, Q3THV9
      Related
      ENSMUSP00000074483.5, ENSMUST00000074950.11
      Conserved Domains (4) summary
      pfam08080
      Location:257 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    2. NM_001313717.1 → NP_001300646.1  heterogeneous nuclear ribonucleoprotein H2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AI853236, AK077716, BX004852, BY227927
      Consensus CDS
      CCDS30397.1
      UniProtKB/Swiss-Prot
      P70333, Q3THV9
      Related
      ENSMUSP00000108829.2, ENSMUST00000113203.2
      Conserved Domains (4) summary
      pfam08080
      Location:257 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    3. NM_019868.4 → NP_063921.1  heterogeneous nuclear ribonucleoprotein H2

      See identical proteins and their annotated locations for NP_063921.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AI853236, AK077716, BX004852, BY135797
      Consensus CDS
      CCDS30397.1
      UniProtKB/Swiss-Prot
      P70333, Q3THV9
      Related
      ENSMUSP00000050838.6, ENSMUST00000059297.6
      Conserved Domains (4) summary
      pfam08080
      Location:257 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133501928..133507809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70333.1 GenPept UniProtKB/Swiss-Prot:P70333

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