Cdc20 cell division cycle 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc20provided by MGI
Official Full Name: cell division cycle 20provided by MGI
Primary source: MGI:MGI:1859866
See related: Ensembl:ENSMUSG00000006398 AllianceGenome:MGI:1859866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p55CDC; 2310042N09Rik
Summary: Predicted to enable several functions, including anaphase-promoting complex binding activity; histone deacetylase binding activity; and ubiquitin ligase activator activity. Involved in metaphase/anaphase transition of meiosis I; positive regulation of synapse maturation; and positive regulation of synaptic plasticity. Acts upstream of or within mitotic sister chromatid cohesion; mitotic spindle assembly; and regulation of meiotic nuclear division. Located in centrosome and kinetochore. Is expressed in several structures, including brain; early conceptus; female reproductive system; hemolymphoid system; and trigeminal ganglion. Orthologous to human CDC20 (cell division cycle 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14.5 (RPKM 69.5), liver E14 (RPKM 66.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 54.61 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (118290098..118294540, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (118432901..118437343, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of beta-catenin.
Title: CDC20 inhibition alleviates fibrotic response of renal tubular epithelial cells and fibroblasts by regulating nuclear translocation of β-catenin.
Septin 9 controls CCNB1 stabilization via APC/C[CDC20] during meiotic metaphase I/anaphase I transition in mouse oocytes.
Title: Septin 9 controls CCNB1 stabilization via APC/C(CDC20) during meiotic metaphase I/anaphase I transition in mouse oocytes.
Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer.
Title: Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer.
Conditional knockout of Cdc20 attenuates osteogenesis in craniofacial bones.
Title: Conditional knockout of Cdc20 attenuates osteogenesis in craniofacial bones.
Oscillation of Cdc20-APC/C-mediated CAMDI stability is critical for cortical neuron migration.
Title: Oscillation of Cdc20-APC/C-mediated CAMDI stability is critical for cortical neuron migration.
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65.
Title: CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65.
CDC20 inhibitor Apcin inhibits embryo implantation in vivo and in vitro.
Title: CDC20 inhibitor Apcin inhibits embryo implantation in vivo and in vitro.
Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development.
Title: Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development.
PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.
Title: PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.
Enforced expression of CDC20 in cardiomyocytes and in the heart aggravated the hypertrophic response. Furthermore, the authors found that CDC20 directly targeted LC3, a key regulator of autophagy, and promoted LC3 ubiquitination and degradation by the proteasome, which inhibited autophagy leading to cardiac hypertrophy.
Title: CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (1) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C87100 (e-PCR)
- UniSTS:209246

Cdc20 (e-PCR), detects polymorphism
- UniSTS:531329

UniSTS:496549 (e-PCR)
- UniSTS:496549

Cdc20 (e-PCR), detects polymorphism
- UniSTS:496549

BB151133 (e-PCR)
- UniSTS:185598

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables anaphase-promoting complex binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	IEA Inferred from Electronic Annotation more info
involved_in anaphase-promoting complex-dependent catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in metaphase/anaphase transition of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in metaphase/anaphase transition of meiosis I	IDA Inferred from Direct Assay more info	PubMed
involved_in metaphase/anaphase transition of meiosis I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic metaphase	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of meiotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	ISO Inferred from Sequence Orthology more info
part_of anaphase-promoting complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of mitotic checkpoint complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division cycle protein 20 homolog

Names: cell division cycle 20 homolog; mmCdc20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023223.2 → NP_075712.2 cell division cycle protein 20 homolog

See identical proteins and their annotated locations for NP_075712.2

Status: VALIDATED

Source sequence(s)

AK168650, AV499208, BY736811

Consensus CDS

CCDS18551.1

UniProtKB/Swiss-Prot

Q3TGP1, Q8BPG4, Q99LK3, Q9JJ66

Related

ENSMUSP00000006565.7, ENSMUST00000006565.13

Conserved Domains (3) summary

COG2319
Location:183 → 473

WD40; WD40 repeat [General function prediction only]

cd00200
Location:190 → 471

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:229 → 266

7WD40; WD40 repeat [structural motif]