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    Nono non-POU-domain-containing, octamer binding protein [ Mus musculus (house mouse) ]

    Gene ID: 53610, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nonoprovided by MGI
    Official Full Name
    non-POU-domain-containing, octamer binding proteinprovided by MGI
    Primary source
    MGI:MGI:1855692
    See related
    Ensembl:ENSMUSG00000031311 AllianceGenome:MGI:1855692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nonA; NRB54; P54NRB
    Summary
    Enables chromatin binding activity. Involved in negative regulation of DNA-templated transcription and regulation of circadian rhythm. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including brain; central nervous system ganglion; gut; sensory organ; and testis. Human ortholog(s) of this gene implicated in cardiomyopathy; intellectual disability; and syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 221.3), CNS E14 (RPKM 143.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nono in Genome Data Viewer
    Location:
    X D; X 44.14 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100473295..100492193)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101429560..101448593)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene gap junction protein, beta 1 Neighboring gene STARR-seq mESC enhancer starr_47649 Neighboring gene zinc finger, MYM-type 3 Neighboring gene STARR-positive B cell enhancer ABC_E7703 Neighboring gene integrin beta 1 binding protein 2 Neighboring gene anaphase promoting complex subunit 13 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Basu A, et al. Mol Cell Biol, 1997 Feb. PMID 9001221, Free PMC Article
    2. NONO regulates B-cell development and B-cell receptor signaling. Zhang Y, et al. FASEB J, 2023 Apr. PMID 36906291
    3. Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency. Ma C, et al. Cell Rep, 2016 Oct 18. PMID 27760330, Free PMC Article
    4. Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes. Li S, et al. DNA Repair (Amst), 2017 Mar. PMID 28209515, Free PMC Article
    5. The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding. Benegiamo G, et al. Cell Metab, 2018 Feb 6. PMID 29358041, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice.
      Title: An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice.
    2. Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription.
      Title: Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription.
    3. LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation.
      Title: LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation.
    4. NONO regulates B-cell development and B-cell receptor signaling.
      Title: NONO regulates B-cell development and B-cell receptor signaling.
    5. NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway.
      Title: NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway.
    6. Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.
      Title: Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.
    7. A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.
      Title: A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.
    8. Transcriptional silencing of fetal hemoglobin expression by NonO.
      Title: Transcriptional silencing of fetal hemoglobin expression by NonO.
    9. Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury.
      Title: Knockout of the NONO Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury.
    10. Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.
      Title: Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (10)  1 citation
    • Gene trapped (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103109

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lncRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to angiotensin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to angiotensin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in paraspeckles ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in paraspeckles ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    non-POU domain-containing octamer-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252518.2 → NP_001239447.1  non-POU domain-containing octamer-binding protein isoform a

      See identical proteins and their annotated locations for NP_001239447.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL831722
      Consensus CDS
      CCDS30316.1
      UniProtKB/Swiss-Prot
      Q63887, Q99K48, Q9CYQ4, Q9DBP2
      UniProtKB/TrEMBL
      Q3TFC2, Q3TTV7, Q4FK11
      Conserved Domains (3) summary
      cd12946
      Location:221 → 313
      NOPS_p54nrb_PSF_PSPC1; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSPC1 family proteins
      cd12588
      Location:75 → 145
      RRM1_p54nrb; RNA recognition motif 1 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
      cl17169
      Location:151 → 230
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001426220.1 → NP_001413149.1  non-POU domain-containing octamer-binding protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AL831722

    3. NM_001426221.1 → NP_001413150.1  non-POU domain-containing octamer-binding protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AL831722

    4. NM_023144.3 → NP_075633.2  non-POU domain-containing octamer-binding protein isoform a

      See identical proteins and their annotated locations for NP_075633.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL831722
      Consensus CDS
      CCDS30316.1
      UniProtKB/Swiss-Prot
      Q63887, Q99K48, Q9CYQ4, Q9DBP2
      UniProtKB/TrEMBL
      Q3TFC2, Q3TTV7, Q4FK11
      Related
      ENSMUSP00000033673.7, ENSMUST00000033673.7
      Conserved Domains (3) summary
      cd12946
      Location:221 → 313
      NOPS_p54nrb_PSF_PSPC1; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSPC1 family proteins
      cd12588
      Location:75 → 145
      RRM1_p54nrb; RNA recognition motif 1 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
      cl17169
      Location:151 → 230
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      100473295..100492193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99K48.3 GenPept UniProtKB/Swiss-Prot:Q99K48

    Gene LinkOut

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