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    Cradd CASP2 and RIPK1 domain containing adaptor with death domain [ Mus musculus (house mouse) ]

    Gene ID: 12905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Craddprovided by MGI
    Official Full Name
    CASP2 and RIPK1 domain containing adaptor with death domainprovided by MGI
    Primary source
    MGI:MGI:1336168
    See related
    Ensembl:ENSMUSG00000045867 AllianceGenome:MGI:1336168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAIDD
    Summary
    Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 6.7), adrenal adult (RPKM 6.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cradd in Genome Data Viewer
    Location:
    10 C2; 10 49.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95010601..95160000, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95174739..95324138, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9348 Neighboring gene predicted gene, 40744 Neighboring gene STARR-seq mESC enhancer starr_27609 Neighboring gene STARR-seq mESC enhancer starr_27611 Neighboring gene predicted gene, 53600 Neighboring gene STARR-positive B cell enhancer mm9_chr10:94613739-94614040 Neighboring gene predicted gene, 29684 Neighboring gene STARR-seq mESC enhancer starr_27617 Neighboring gene STARR-positive B cell enhancer mm9_chr10:94720661-94720962 Neighboring gene STARR-positive B cell enhancer mm9_chr10:94723743-94724044 Neighboring gene STARR-seq mESC enhancer starr_27622 Neighboring gene STARR-positive B cell enhancer ABC_E6911 Neighboring gene STARR-seq mESC enhancer starr_27628 Neighboring gene RIKEN cDNA 2310039L15 gene Neighboring gene STARR-seq mESC enhancer starr_27629 Neighboring gene STARR-seq mESC enhancer starr_27631 Neighboring gene STARR-positive B cell enhancer ABC_E3909 Neighboring gene STARR-positive B cell enhancer mm9_chr10:94834542-94834843 Neighboring gene STARR-seq mESC enhancer starr_27632 Neighboring gene STARR-positive B cell enhancer ABC_E5173 Neighboring gene suppressor of cytokine signaling 2 Neighboring gene predicted gene, 33230

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of CRADD-caspase 2 cascade by histone deacetylase 1 in gastric cancer. Shen Q, et al. Am J Transl Res, 2014. PMID 25360218, Free PMC Article
    2. In situ analysis of Raidd-beta-galactosidase fusion gene expression in transgenic mouse midgestation embryos. Motaln H, et al. Transgenic Res, 2005 Feb. PMID 15865046
    3. Overexpression of Raidd cDNA inhibits differentiation of mouse preadipocytes. Felmer R, et al. Cell Prolif, 2003 Feb. PMID 12558660, Free PMC Article
    4. The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli. Qiao H, et al. J Biol Chem, 2014 Aug 8. PMID 24958727, Free PMC Article
    5. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Kim JY, et al. Cell Metab, 2022 Oct 4. PMID 36041455, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd
      Title: The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
    2. define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists
      Title: The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.
    3. Neuronal caspase-2-dependent execution of neurons requires recptor-interacting protein RAIDD, not p53-inducible protein with a death domain (PIDD).
      Title: Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.
    4. We show that CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1
      Title: Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.
    5. P53-induced protein with a death domain -induced apoptosis and growth suppression in embryonic fibroblasts depend on the adaptor protein receptor-interacting protein (RIP)-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD).
      Title: Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
    6. Overexpression of Raidd cDNA in 3T3L1 cells inhibited differentiation of the preadipocytes.
      Title: Overexpression of Raidd cDNA inhibits differentiation of mouse preadipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables death domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables death domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of endopeptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    death domain-containing protein CRADD
    Names
    RIP-associated protein with a death domain
    caspase and RIP adapter with death domain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330138.1 → NP_001317067.1  death domain-containing protein CRADD

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AA109538, AC153940, AI430259, BE991734, BQ571215
      Consensus CDS
      CCDS24135.1
      UniProtKB/Swiss-Prot
      O88843, Q9QUN0
      UniProtKB/TrEMBL
      Q549T4
      Related
      ENSMUSP00000151735.2, ENSMUST00000217809.2
      Conserved Domains (2) summary
      cd08319
      Location:116 → 198
      Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    2. NM_001330141.1 → NP_001317070.1  death domain-containing protein CRADD

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AA109538, AC153366, AC153940, AV581600, BE991734
      Consensus CDS
      CCDS24135.1
      UniProtKB/Swiss-Prot
      O88843, Q9QUN0
      UniProtKB/TrEMBL
      Q549T4
      Conserved Domains (2) summary
      cd08319
      Location:116 → 198
      Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    3. NM_001330175.1 → NP_001317104.1  death domain-containing protein CRADD

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AA109538, AC153366, AC153940, AI426523, BE991734
      Consensus CDS
      CCDS24135.1
      UniProtKB/Swiss-Prot
      O88843, Q9QUN0
      UniProtKB/TrEMBL
      Q549T4
      Conserved Domains (2) summary
      cd08319
      Location:116 → 198
      Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    4. NM_009950.3 → NP_034080.1  death domain-containing protein CRADD

      See identical proteins and their annotated locations for NP_034080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AA109538, AC153366, AC153940, AK163112, BE991734
      Consensus CDS
      CCDS24135.1
      UniProtKB/Swiss-Prot
      O88843, Q9QUN0
      UniProtKB/TrEMBL
      Q549T4
      Related
      ENSMUSP00000050295.6, ENSMUST00000053594.7
      Conserved Domains (2) summary
      cd08319
      Location:116 → 198
      Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      95010601..95160000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513180.2 → XP_006513243.1  death domain-containing protein CRADD isoform X1

      See identical proteins and their annotated locations for XP_006513243.1

      UniProtKB/Swiss-Prot
      O88843, Q9QUN0
      UniProtKB/TrEMBL
      Q549T4
      Related
      ENSMUSP00000152022.2, ENSMUST00000220279.2
      Conserved Domains (2) summary
      cd08319
      Location:116 → 198
      Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    2. XM_006513181.4 → XP_006513244.1  death domain-containing protein CRADD isoform X1

      See identical proteins and their annotated locations for XP_006513244.1

      UniProtKB/Swiss-Prot
      O88843, Q9QUN0
      UniProtKB/TrEMBL
      Q549T4
      Conserved Domains (2) summary
      cd08319
      Location:116 → 198
      Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    3. XM_030244859.2 → XP_030100719.1  death domain-containing protein CRADD isoform X2

      UniProtKB/TrEMBL
      Q3UMW0
      Conserved Domains (1) summary
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    4. XM_006513184.5 → XP_006513247.1  death domain-containing protein CRADD isoform X2

      See identical proteins and their annotated locations for XP_006513247.1

      UniProtKB/TrEMBL
      Q3UMW0
      Conserved Domains (1) summary
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    5. XM_006513183.5 → XP_006513246.1  death domain-containing protein CRADD isoform X2

      See identical proteins and their annotated locations for XP_006513246.1

      UniProtKB/TrEMBL
      Q3UMW0
      Conserved Domains (1) summary
      cd08327
      Location:1 → 94
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88843.2 GenPept UniProtKB/Swiss-Prot:O88843

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