Chrna2 cholinergic receptor nicotinic alpha 2 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chrna2provided by MGI
Official Full Name: cholinergic receptor nicotinic alpha 2 subunitprovided by MGI
Primary source: MGI:MGI:87886
See related: Ensembl:ENSMUSG00000022041 AllianceGenome:MGI:87886
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acra2; Acra-2
Summary: Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity and quaternary ammonium group binding activity. Predicted to contribute to acetylcholine receptor activity and heterocyclic compound binding activity. Predicted to be involved in several processes, including cellular response to nicotine; modulation of inhibitory postsynaptic potential; and synaptic signaling. Located in cell periphery. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4 and benign familial infantile seizures 6. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in genital fat pad adult (RPKM 6.8), ovary adult (RPKM 1.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.36 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (66370685..66390397)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (66133236..66152948)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hippocampal knockdown of alpha2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning.
Title: Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning.
Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.
Title: Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.
These results reveal a beige-selective immune-adipose interaction mediated through CHRNA2 and identify a novel function of nicotinic acetylcholine receptors in energy metabolism.
Title: An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling.
The results of this study demonstrated that alpha2* nAChRs influenced hippocampus-dependent learning and memory, as well as nicotine-facilitated CA1 hippocampal synaptic plasticity.
Title: α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice.
Chrna2-expressing Martinotti cells selectively target L5 thick-tufted type A pyramidal cells (PCs) but not thin-tufted type B PCs.
Title: Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation.
Study described Chrna2 expression in the amygdala and propose that this expression is a marker of the medial subpallium-derived amygdala
Title: The α2-subunit of the nicotinic cholinergic receptor is specifically expressed in medial subpallium-derived cells of mammalian amygdala.
These results demonstrate that nicotine withdrawal enhances neuronal activity within the interpeduncular nucleus and dorsal hippocampus, which is absent in mice null for alpha2-containing nAChRs.
Title: α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression.
The results of this study suggested that loss of the mouse nAChR alpha2 subunit has very limited effects on baseline behavior but does lead to the potentiation of several nicotine-modulated behaviors.
Title: Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

UniSTS:496005 (e-PCR)
- UniSTS:496005

Chrna2 (e-PCR), detects polymorphism
- UniSTS:496005

Chrna2 (e-PCR), detects polymorphism
- UniSTS:256422

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor activity	IEA Inferred from Electronic Annotation more info
enables acetylcholine receptor activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
enables acetylcholine-gated monoatomic cation-selective channel activity	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	IEA Inferred from Electronic Annotation more info
contributes_to heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables quaternary ammonium group binding	IEA Inferred from Electronic Annotation more info
enables quaternary ammonium group binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of inhibitory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in modulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to acetylcholine	IEA Inferred from Electronic Annotation more info
involved_in response to acetylcholine	ISO Inferred from Sequence Orthology more info
involved_in response to nicotine	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, cholinergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IEA Inferred from Electronic Annotation more info
part_of acetylcholine-gated channel complex	ISO Inferred from Sequence Orthology more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection cytoplasm	IEA Inferred from Electronic Annotation more info
located_in neuron projection cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit alpha-2

Names: cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001425568.1 → NP_001412497.1 neuronal acetylcholine receptor subunit alpha-2 precursor

Status: VALIDATED

Source sequence(s)

AC126272

UniProtKB/Swiss-Prot

Q91X60

Related

ENSMUSP00000145896.2, ENSMUST00000206455.2
NM_144803.3 → NP_659052.1 neuronal acetylcholine receptor subunit alpha-2 precursor

See identical proteins and their annotated locations for NP_659052.1

Status: VALIDATED

Source sequence(s)

AC126272

Consensus CDS

CCDS27219.1

UniProtKB/Swiss-Prot

Q91X60

Related

ENSMUSP00000022620.10, ENSMUST00000022620.11

Conserved Domains (2) summary

TIGR00860
Location:15 → 505

LIC; Cation transporter family protein

cd19015
Location:36 → 242

LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

66370685..66390397

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518436.4 → XP_006518499.1 neuronal acetylcholine receptor subunit alpha-2 isoform X1

See identical proteins and their annotated locations for XP_006518499.1

UniProtKB/Swiss-Prot

Q91X60

Conserved Domains (2) summary

TIGR00860
Location:15 → 505

LIC; Cation transporter family protein

cd19015
Location:36 → 242

LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)
XM_006518435.3 → XP_006518498.1 neuronal acetylcholine receptor subunit alpha-2 isoform X1

See identical proteins and their annotated locations for XP_006518498.1

UniProtKB/Swiss-Prot

Q91X60

Conserved Domains (2) summary

TIGR00860
Location:15 → 505

LIC; Cation transporter family protein

cd19015
Location:36 → 242

LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)