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    PLC2 phospholipase C 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819999, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PLC2
    Official Full Name
    phospholipase C 2
    Primary source
    TAIR:AT3G08510
    Locus tag
    AT3G08510
    See related
    Araport:AT3G08510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPLC2; phospholipase C 2
    Summary
    Phosphoinositide-specific phospholipase C (PI-PLC), catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate into inositol 1,4,5-trisphosphate and diacylglycerol.
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    Genomic context

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    See PLC2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (2582362..2585898, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene zinc finger (CCCH-type/C3HC4-type RING finger) family protein Neighboring gene Ribosomal protein L41 family Neighboring gene Clathrin, heavy chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis phosphatidylinositol-phospholipase C2 (PLC2) is required for female gametogenesis and embryo development. Di Fino LM, et al. Planta, 2017 Apr. PMID 27999988
    2. Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response. Kanehara K, et al. PLoS Genet, 2015 Sep. PMID 26401841, Free PMC Article
    3. Arabidopsis PLC2 is involved in auxin-modulated reproductive development. Li L, et al. Plant J, 2015 Nov. PMID 26340337
    4. AtPLC2, a gene encoding phosphoinositide-specific phospholipase C, is constitutively expressed in vegetative and floral tissues in Arabidopsis thaliana. Hirayama T, et al. Plant Mol Biol, 1997 May. PMID 9177324
    5. Phosphatidylinositol-specific phospholipase C2 functions in auxin-modulated root development. Chen X, et al. Plant Cell Environ, 2019 May. PMID 30496625

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate a critical role of PLC2 in auxin-mediated root development in Arabidopsis, in which PLC2 influences the polar distribution of PIN2.
      Title: Phosphatidylinositol-specific phospholipase C2 functions in auxin-modulated root development.
    2. The generation of reactive oxygen species (ROS) upon flg22 treatment is compromised in the PLC2-defficient plants, suggesting an effect of PLC2 in a branch of MAMP-triggered immunity and nonhost resistance that involves early ROS-regulated processes. Consistently, PLC2 associates with the NADPH oxidase RBOHD, suggesting its potential regulation by PLC2.
      Title: Phospholipase C2 Affects MAMP-Triggered Immunity by Modulating ROS Production.
    3. essential for female gametogenesis and embryo development
      Title: Arabidopsis phosphatidylinositol-phospholipase C2 (PLC2) is required for female gametogenesis and embryo development.
    4. PLC2 is involved in auxin biosynthesis and signaling, thus modulating development of both male and female gametophytes in Arabidopsis.
      Title: Arabidopsis PLC2 is involved in auxin-modulated reproductive development.
    5. seedlings of plc2-1 mutant showed growth defect that was complemented by heterologous expression of AtPLC2, suggesting that phosphoinositide-specific phospholipase C activity borne by AtPLC2 is required for seedling growth
      Title: Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response.
    6. AtPI4KIIIbeta1 and AtPI4KIIIbeta2 can both act upstream of the PI-PLC. There is evidence for the occurrence of a de novo synthesis of PtdIns4P by PI4K that coincides with PI-PLC activation. [PI-PLC]
      Title: Arabidopsis type-III phosphatidylinositol 4-kinases β1 and β2 are upstream of the phospholipase C pathway triggered by cold exposure.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035583.1
    NM_001161124.1
    NM_001337760.1
    NM_111686.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase C activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microsporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of auxin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    phospholipase C 2
    NP_001030660.1
    • phospholipase C 2 (PLC2); FUNCTIONS IN: phospholipase C activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT3G55940.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001154596.1
    • phospholipase C 2; FUNCTIONS IN: phospholipase C activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT3G55940.1); Has 2455 Blast hits to 1965 proteins in 253 species: Archae - 0; Bacteria - 0; Metazoa - 1631; Fungi - 365; Plants - 250; Viruses - 0; Other Eukaryotes - 209 (source: NCBI BLink).
    NP_187464.1
    • phospholipase C 2 (PLC2); FUNCTIONS IN: phospholipase C activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), C2 calcium-dependent membrane targeting (InterPro:IPR000008), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT3G55940.1); Has 2471 Blast hits to 1979 proteins in 261 species: Archae - 0; Bacteria - 0; Metazoa - 1631; Fungi - 374; Plants - 251; Viruses - 0; Other Eukaryotes - 215 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2582362..2585898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111686.6 → NP_187464.1  phospholipase C 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39033, Q56XL3, Q8LG47
      UniProtKB/TrEMBL
      A0A178VDK7, A0A384L124, A0A5S9XAG6, C0Z2P3
      Conserved Domains (1) summary
      PLN02222
      Location:1 → 581
      PLN02222; phosphoinositide phospholipase C 2

    2. NM_001337760.1 → NP_001327169.1  phospholipase C 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XAG6, F4IX90

    3. NM_001161124.1 → NP_001154596.1  phospholipase C 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XAG6, F4IX90
      Conserved Domains (4) summary
      cd00275
      Location:431 → 551
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02222
      Location:1 → 552
      PLN02222; phosphoinositide phospholipase C 2
      pfam09279
      Location:26 → 102
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:102 → 420
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    4. NM_001035583.1 → NP_001030660.1  phospholipase C 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030660.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39033, Q56XL3, Q8LG47
      UniProtKB/TrEMBL
      A0A178VDK7, A0A384L124, A0A5S9XAG6, C0Z2P3
      Conserved Domains (1) summary
      PLN02222
      Location:1 → 581
      PLN02222; phosphoinositide phospholipase C 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39033.1

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