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    PAD2 proteasome alpha subunit D2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836746, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAD2
    Official Full Name
    proteasome alpha subunit D2
    Primary source
    TAIR:AT5G66140
    Locus tag
    AT5G66140
    See related
    Araport:AT5G66140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    20S PROTEASOME SUBUNIT PAD2; K2A18.22; K2A18_22; proteasome alpha subunit D2
    Summary
    Encodes alpha5 subunit of 20S proteosome complex involved in protein degradation.
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    Genomic context

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    See PAD2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (26437170..26438771, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene winged-helix DNA-binding transcription factor family protein Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene 3-dehydroquinate synthase Neighboring gene RADIATION SENSITIVE 17 Neighboring gene Glycosyl hydrolase family 38 protein Neighboring gene receptor homology region transmembrane domain ring H2 motif protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glutathione-deficient mutant pad2-1 accumulates lower amounts of glucosinolates and is more susceptible to the insect herbivore Spodoptera littoralis. Schlaeppi K, et al. Plant J, 2008 Sep. PMID 18466300
    2. Identification of PAD2 as a gamma-glutamylcysteine synthetase highlights the importance of glutathione in disease resistance of Arabidopsis. Parisy V, et al. Plant J, 2007 Jan. PMID 17144898
    3. Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana. Fu H, et al. Genetics, 1998 Jun. PMID 9611183, Free PMC Article
    4. The 20S proteasome gene family in Arabidopsis thaliana. Parmentier Y, et al. FEBS Lett, 1997 Oct 27. PMID 9373170
    5. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAD2 encodes a gamma-glutamylcysteine synthetase involved in glutathione synthesis. pad2-1 mutants are glutathione-deficient and are more susceptible to Spodoptera littoralis because of a lower accumulation of glucosinolates.
      Title: The glutathione-deficient mutant pad2-1 accumulates lower amounts of glucosinolates and is more susceptible to the insect herbivore Spodoptera littoralis.
    2. The effect of PAD2 mutations on the susceptibility of A. thaliana to bacterial diseases is reported.
      Title: Identification of PAD2 as a gamma-glutamylcysteine synthetase highlights the importance of glutathione in disease resistance of Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_126012.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plastid HDA PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    proteasome alpha subunit D2
    NP_201415.1
    • proteasome alpha subunit D2 (PAD2); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, proteasome core complex, alpha-subunit complex, chloroplast, vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: 20S proteasome alpha subunit PAD1 (TAIR:AT3G51260.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26437170..26438771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126012.4 → NP_201415.1  proteasome alpha subunit D2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201415.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24616, Q0WTK1, Q84W05
      UniProtKB/TrEMBL
      A0A178UMI1, A0A5S9YHF6
      Conserved Domains (2) summary
      PRK03996
      Location:1 → 229
      PRK03996; proteasome subunit alpha; Provisional
      cd03755
      Location:4 → 210
      proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O24616.2

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