ROC4 rotamase CYP 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ROC4
Official Full Name: rotamase CYP 4
Primary source: TAIR:AT3G62030
Locus tag: AT3G62030
See related: Araport:AT3G62030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: cyclophilin 20-3; CYP20-3; PEPTIDYLPROLYL ISOMERASE ROC4; rotamase CYP 4; T17J13.1
Summary: nuclear-encoded chloroplast stromal cyclophilin CYP20-3 (also known as ROC4). Protein is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.
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Genomic context

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See ROC4 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 9

Sequence:: Chromosome: 3; NC_003074.8 (22973004..22975378)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interplay between MYZUS PERSICAE-INDUCED LIPASE 1 and OPDA signaling in limiting green peach aphid infestation on Arabidopsis thaliana.
Title: Interplay between MYZUS PERSICAE-INDUCED LIPASE 1 and OPDA signaling in limiting green peach aphid infestation on Arabidopsis thaliana.
These quantitative data support a model where 2-CysPrx and Cyp20-3, by interaction, form a redox-sensitive regulatory module in the chloroplast which is under control of the photosynthesis-linked stromal pH value, the redox state and additional stromal protein factor(s).
Title: Redox-Dependent Conformational Dynamics of Decameric 2-Cysteine Peroxiredoxin and its Interaction with Cyclophilin 20-3.
Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis.
Title: Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis.
ROC4 functions in the repair of photodamaged photosystem II
Title: Function of ROC4 in the efficient repair of photodamaged photosystem II in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001161212.1

Supported by ESTs:

NM_001203230.1

Supported by ESTs:

NM_116068.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cysteine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein peptidyl-prolyl isomerization	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in protein targeting to chloroplast	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to light intensity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to mannitol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast thylakoid membrane	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed
located_in thylakoid lumen	HDA more info	PubMed

General protein information

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Preferred Names: rotamase CYP 4

NP_001154684.1

rotamase CYP 4 (ROC4); CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: cyclophilin 20-2 (TAIR:AT5G13120.1); Has 16678 Blast hits to 16640 proteins in 2710 species: Archae - 109; Bacteria - 6942; Metazoa - 2940; Fungi - 1352; Plants - 1326; Viruses - 4; Other Eukaryotes - 4005 (source: NCBI BLink).

NP_001190159.1

rotamase CYP 4 (ROC4); CONTAINS InterPro DOMAIN/s: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: cyclophilin 20-2 (TAIR:AT5G13120.1).

NP_191762.1

rotamase CYP 4 (ROC4); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: in 9 processes; LOCATED IN: in 8 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: cyclophilin 20-2 (TAIR:AT5G13120.1); Has 16567 Blast hits to 16531 proteins in 2704 species: Archae - 108; Bacteria - 6870; Metazoa - 2913; Fungi - 1380; Plants - 1296; Viruses - 4; Other Eukaryotes - 3996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

22973004..22975378

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001161212.1 → NP_001154684.1 rotamase CYP 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154684.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2EW04, F4IX26

Conserved Domains (1) summary

cd01926
Location:149 → 307

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
NM_001203230.1 → NP_001190159.1 rotamase CYP 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190159.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2EW04, F4IX28

Conserved Domains (1) summary

cd01926
Location:95 → 253

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
NM_116068.5 → NP_191762.1 rotamase CYP 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191762.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34791, Q8LBZ9, Q9FPH5

UniProtKB/TrEMBL

A0A178VJX5, A0A5S9XN86, A0A7G2EW04

Conserved Domains (1) summary

cd01926
Location:96 → 254

cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...