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    scg2a secretogranin II a [ Danio rerio (zebrafish) ]

    Gene ID: 793796, updated on 24-Nov-2024

    Summary

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    Official Symbol
    scg2aprovided by ZNC
    Official Full Name
    secretogranin II aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8214
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-8214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sgIIa; fj60f08; wu:fj60f08
    Summary
    Predicted to be located in extracellular region and secretory granule. Is expressed in brain; female organism; gut; and male organism. Orthologous to human SCG2 (secretogranin II). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See scg2a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (43142920..43144806)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (43261948..43264148)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase long chain family member 3a Neighboring gene uncharacterized LOC101882929 Neighboring gene uncharacterized LOC137487676 Neighboring gene potassium voltage-gated channel, Isk-related family, member 4 Neighboring gene adaptor related protein complex 1 subunit sigma 3a Neighboring gene dehydrogenase/reductase 12-like a Neighboring gene WD repeat and FYVE domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Estrogen-dependent expression and function of secretogranin 2a in female-specific peptidergic neurons. Fleming T, et al. PNAS Nexus, 2023 Dec. PMID 38111823, Free PMC Article
    2. Secretoneurin is a secretogranin-2 derived hormonal peptide in vertebrate neuroendocrine systems. Mitchell K, et al. Gen Comp Endocrinol, 2020 Dec 1. PMID 32828813
    3. Arginine vasopressin injection rescues delayed oviposition in cyp19a1b(-/-) mutant female zebrafish. Shaw K, et al. Front Endocrinol (Lausanne), 2023. PMID 38144569, Free PMC Article
    4. Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish. Mitchell K, et al. Proc Natl Acad Sci U S A, 2020 Jun 9. PMID 32467166, Free PMC Article
    5. Knockout of the Gnrh genes in zebrafish: effects on reproduction and potential compensation by reproductive and feeding-related neuropeptides. Marvel M, et al. Biol Reprod, 2018 Sep 1. PMID 29635430

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish.
      Title: Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secretogranin-2a
    Names
    Secretogranin-2a
    secretogranin II (chromogranin C) a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423991.1 → NP_001410920.1  secretogranin-2a precursor

      Status: VALIDATED

      Source sequence(s)
      FO704834
      UniProtKB/Swiss-Prot
      C0HM54
      UniProtKB/TrEMBL
      A0A8M3AHQ7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      43142920..43144806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HM54.1 GenPept UniProtKB/Swiss-Prot:C0HM54

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